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Toggle | Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings | Nature Communications | Keivan Rahmani, Yang Yang, Ethan Paul Foster, et al. | 2025 | 2041-1723 | |
PubMed Record
Publication TypeJournal ArticleAbstractIntracellular electrophysiology is essential in neuroscience, cardiology, and pharmacology for studying cells’ electrical properties. Traditional methods like patch-clamp are precise but low-throughput and invasive. Nanoelectrode Arrays (NEAs) offer a promising alternative by enabling simultaneous intracellular and extracellular action potential (iAP and eAP) recordings with high throughput. However, accessing intracellular potentials with NEAs remains challenging. This study presents an AI-supported technique that leverages thousands of synchronous eAP and iAP pairs from stem-cell-derived cardiomyocytes on NEAs. Our analysis revealed strong correlations between specific eAP and iAP features, such as amplitude and spiking velocity, indicating that extracellular signals could be reliable indicators of intracellular activity. We developed a physics-informed deep learning model to reconstruct iAP waveforms from extracellular recordings recorded from NEAs and Microelectrode arrays (MEAs), demonstrating its potential for non-invasive, long-term, high-throughput drug cardiotoxicity assessments. This AI-based model paves the way for future electrophysiology research across various cell types and drug interactions. JournalNature CommunicationsPublication Volume16Publication Issue1Pagination657Published2025/01/14Issn2041-1723AuthorsKeivan Rahmani, Yang Yang, Ethan Paul Foster, et al.DOI10.1038/s41467-024-55571-6 Google Scholar Pubmed |
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Toggle | Spatial modeling algorithms for reactions and transport in biological cells | Nature Computational Science | Emmet A. Francis, Justin G. Laughlin, Jørgen S. Dokken, et al. | 2024 | 2662-8457 | |
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Publication TypeJournal ArticleAbstractBiological cells rely on precise spatiotemporal coordination of biochemical reactions to control their functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate, particularly in realistic cell geometries. Here we present Spatial Modeling Algorithms for Reactions and Transport (SMART), a software package that takes in high-level user specifications about cell signaling networks and then assembles and solves the associated mathematical systems. SMART uses state-of-the-art finite element analysis, via the FEniCS Project software, to efficiently and accurately resolve cell signaling events over discretized cellular and subcellular geometries. We demonstrate its application to several different biological systems, including yes-associated protein (YAP)/PDZ-binding motif (TAZ) mechanotransduction, calcium signaling in neurons and cardiomyocytes, and ATP generation in mitochondria. Throughout, we utilize experimentally derived realistic cellular geometries represented by well-conditioned tetrahedral meshes. These scenarios demonstrate the applicability, flexibility, accuracy and efficiency of SMART across a range of temporal and spatial scales. JournalNature Computational SciencePublication Issue5Pagination76-89Published2024/12/19Issn2662-8457AuthorsEmmet A. Francis, Justin G. Laughlin, Jørgen S. Dokken, et al.DOI10.1038/s43588-024-00745-x Google Scholar Pubmed |
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Toggle | Active vision in freely moving marmosets using head-mounted eye tracking | bioRxiv | Vikram Pal Singh, Jingwen Li, Kana Dawson, et al. | 2024 | 2692-8205 | |
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Publication TypeJournal ArticleAbstractOur understanding of how vision functions as primates actively navigate the real-world is remarkably sparse. As most data have been limited to chaired and typically head-restrained animals, the synergistic interactions of different motor actions/plans inherent to active sensing – e.g. eyes, head, posture, movement, etc. – on visual perception are largely unknown. To address this considerable gap in knowledge, we developed an innovative wireless head-mounted eye tracking system called CEREBRO for small mammals, such as marmoset monkeys. Our system performs Chair-free Eye-Recording using Backpack mounted micROcontrollers. Because eye illumination and environment lighting change continuously in natural contexts, we developed a segmentation artificial neural network to perform robust pupil tracking in these conditions. Leveraging this innovative system to investigate active vision, we demonstrate that although freely-moving marmosets exhibit frequent compensatory eye movements equivalent to other primates, including humans, the predictability of the visual behavior (gaze) is higher when animals are freely-moving relative to when they are head-fixed. Moreover, despite increases in eye/head-motion during locomotion, gaze stabilization remains steady because of an increase in VOR gain during locomotion. These results demonstrate the efficient, dynamic visuo-motor mechanisms and related behaviors that enable stable, high-resolution foveal vision in primates as they explore the natural world. JournalbioRxivPublished2024/11/21Issn2692-8205AuthorsVikram Pal Singh, Jingwen Li, Kana Dawson, et al.KeywordsActive-vision; Marmosets; eye-tracking; gaze stabilization.DOI10.1101/2024.05.11.593707 Google Scholar Pubmed |
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Toggle | A top-down slow breathing circuit that alleviates negative affect in mice | Nature Neuroscience | Jhang, J., Park, et al. | 2024 | 1546-1726 | |
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Publication TypeJournal ArticleAbstractAlthough breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem respiratory networks, which hitherto have received little characterization. Here we identify in mice a top-down breathing pathway from dorsal anterior cingulate cortex (dACC) neurons to pontine reticular nucleus GABAergic inhibitory neurons (PnCGABA), which then project to the ventrolateral medulla (VLM). dACC→PnC activity correlates with slow breathing cycles and volitional orofacial behaviors and is influenced by anxiogenic conditions. Optogenetic stimulation of the dACC→PnCGABA→VLM circuit simultaneously slows breathing and suppresses anxiety-like behaviors, whereas optogenetic inhibition increases both breathing rate and anxiety-like behaviors. These findings suggest that the dACC→PnCGABA→VLM circuit has a crucial role in coordinating slow breathing and reducing negative affect. Our study elucidates a circuit basis for top-down control of breathing, which can influence emotional states. JournalNature NeurosciencePublication Volume27Publication Issue11Issn1546-1726AuthorsJhang, J., Park, et al.DOI10.1038/s41593-024-01799-w Google Scholar Pubmed |
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Toggle | Development of neural circuits for social motion perception in schooling fish | Current Biology | Zada D, Schulze L, Yu J, et al. | 2024 | 0960-9822 | |
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Publication TypeJournal ArticleAbstractThe collective behavior of animal groups emerges from the interactions among individuals. These social interactions produce the coordinated movements of bird flocks and fish schools, but little is known about their developmental emergence and neurobiological foundations. By characterizing the visually based schooling behavior of the micro glassfish Danionella cerebrum, we found that social development progresses sequentially, with animals first acquiring the ability to aggregate, followed by postural alignment with social partners. This social maturation was accompanied by the development of neural populations in the midbrain that were preferentially driven by visual stimuli that resemble the shape and movements of schooling fish. Furthermore, social isolation over the course of development impaired both schooling behavior and the neural encoding of social motion in adults. This work demonstrates that neural populations selective for the form and motion of conspecifics emerge with the experience-dependent development of collective movement. JournalCurrent BiologyPublication Volume34Publication Issue15Pagination3380-3391.e5Issn0960-9822AuthorsZada D, Schulze L, Yu J, et al.KeywordsDanionella cerebrum; collective behavior; neural dynamics; social development; visual systems.DOI10.1016/j.cub.2024.06.049 Google Scholar Pubmed |
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Toggle | Peripheral preprocessing in Drosophila facilitates odor classification | Proceedings of the National Academy of Sciences of the United States of America | Palka Puri, Shiuan-Tze Wu, Chih-Ying Su, et al. | 2024 | 0027-8424 | |
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Publication TypeJournal ArticleAbstractThe mammalian brain implements sophisticated sensory processing algorithms along multilayered (“deep”) neural networks. Strategies that insects use to meet similar computational demands, while relying on smaller nervous systems with shallow architectures, remain elusive. Using Drosophila as a model, we uncover the algorithmic role of odor preprocessing by a shallow network of compartmentalized olfactory receptor neurons. Each compartment operates as a ratiometric unit for specific odor-mixtures. This computation arises from a simple mechanism: electrical coupling between two differently sized neurons. We demonstrate that downstream synaptic connectivity is shaped to optimally leverage amplification of a hedonic value signal in the periphery. Furthermore, peripheral preprocessing is shown to markedly improve novel odor classification in a higher brain center. Together, our work highlights a far-reaching functional role of the sensory periphery for downstream processing. By elucidating the implementation of powerful computations by a shallow network, we provide insights into general principles of efficient sensory processing algorithms. JournalProceedings of the National Academy of Sciences of the United States of AmericaPublication Volume121Publication Issue21Published2024/04/16Issn0027-8424AuthorsPalka Puri, Shiuan-Tze Wu, Chih-Ying Su, et al.DOI10.1073/pnas.2316799121 Google Scholar Pubmed |
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Toggle | Generalized fear after acute stress is caused by change in neuronal cotransmitter identity | Science | Hui-Quan Li, Wuji Jiang, Li Ling, et al. | 2024 | 1095-9203 | |
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Publication TypeJournal ArticleAbstractOvergeneralization of fear to harmless situations is a core feature of anxiety disorders resulting from acute stress, yet the mechanisms by which fear becomes generalized are poorly understood. In this study, we show that generalized fear in mice results from a transmitter switch from glutamate to γ-aminobutyric acid (GABA) in serotonergic neurons of the lateral wings of the dorsal raphe. Similar change in transmitter identity was found in the postmortem brains of individuals with posttraumatic stress disorder (PTSD). Overriding the transmitter switch in mice prevented the acquisition of generalized fear. Corticosterone release and activation of glucocorticoid receptors mediated the switch, and prompt antidepressant treatment blocked the cotransmitter switch and generalized fear. Our results provide important insight into the mechanisms involved in fear generalization. JournalSciencePublication Volume383Publication Issue6688Pagination1252-1259Issn1095-9203AuthorsHui-Quan Li, Wuji Jiang, Li Ling, et al.DOI10.1126/science.adj5996 Google Scholar Pubmed |
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Toggle | Dopamine signaling regulates predator-driven changes in egg laying behavior. | eLife | Pribadi A, Rieger MA, Rosales K, et al. | 2023 | 2050-084X | |
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Publication TypeJournal ArticleAbstractPrey respond to predators by altering their behavior to optimize their own fitness and survival. Specifically, prey are known to avoid predator-occupied territories to reduce their risk of harm or injury to themselves and their progeny. We probe the interactions between and its naturally cohabiting predator to reveal the pathways driving changes in prey behavior. While prefers to lay its eggs on a bacteria food lawn, the presence of a predator inside a lawn induces to lay more eggs away from that lawn. We confirm that this change in egg laying is in response to bites from predators, rather than to predatory secretions. Moreover, predator-exposed prey continue to lay their eggs away from the dense lawn even after the predator is removed, indicating a form of learning. Next, we find that mutants in dopamine synthesis significantly reduce egg laying behavior off the lawn in both predator-free and predator-inhabited lawns, which we can rescue by transgenic complementation or supplementation with exogenous dopamine. Moreover, we find that dopamine is likely released from multiple dopaminergic neurons and requires combinations of both D1- (DOP-1) and D2-like (DOP-2 and DOP-3) dopamine receptors to alter predator-induced egg laying behavior, whereas other combinations modify baseline levels of egg laying behavior. Together, we show that dopamine signaling can alter both predator-free and predator-induced foraging strategies, suggesting a role for this pathway in defensive behaviors. JournaleLifePublication Volume12Issn2050-084XAuthorsPribadi A, Rieger MA, Rosales K, et al.KeywordsC. elegans, P. uniformis, dopamine, egg laying, neuroscience, predator-preyDOI10.7554/eLife.83957 Google Scholar Pubmed |
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Toggle | Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus). | Frontiers in aging neuroscience | Glavis-Bloom C, Vanderlip CR, Weiser Novak S, et al. | 2023 | 1663-4365 | |
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Publication TypeJournal ArticleAbstractMorphology and function of the dorsolateral prefrontal cortex (dlPFC), and corresponding working memory performance, are affected early in the aging process, but nearly half of aged individuals are spared of working memory deficits. Translationally relevant model systems are critical for determining the neurobiological drivers of this variability. The common marmoset (Callithrix jacchus) is advantageous as a model for these investigations because, as a non-human primate, marmosets have a clearly defined dlPFC that enables measurement of prefrontal-dependent cognitive functions, and their short (∼10 year) lifespan facilitates longitudinal studies of aging. Previously, we characterized working memory capacity in a cohort of marmosets that collectively covered the lifespan, and found age-related working memory impairment. We also found a remarkable degree of heterogeneity in performance, similar to that found in humans. Here, we tested the hypothesis that changes to synaptic ultrastructure that affect synaptic efficacy stratify marmosets that age with cognitive impairment from those that age without cognitive impairment. We utilized electron microscopy to visualize synapses in the marmoset dlPFC and measured the sizes of boutons, presynaptic mitochondria, and synapses. We found that coordinated scaling of the sizes of synapses and mitochondria with their associated boutons is essential for intact working memory performance in aged marmosets. Further, lack of synaptic scaling, due to a remarkable failure of synaptic mitochondria to scale with presynaptic boutons, selectively underlies age-related working memory impairment. We posit that this decoupling results in mismatched energy supply and demand, leading to impaired synaptic transmission. We also found that aged marmosets have fewer synapses in dlPFC than young, though the severity of synapse loss did not predict whether aging occurred with or without cognitive impairment. This work identifies a novel mechanism of synapse dysfunction that stratifies marmosets that age with cognitive impairment from those that age without cognitive impairment. The process by which synaptic scaling is regulated is yet unknown and warrants future investigation. JournalFrontiers in aging neurosciencePublication Volume15Pagination1146245Issn1663-4365AuthorsGlavis-Bloom C, Vanderlip CR, Weiser Novak S, et al.Keywordsaging, electron microscopy, marmoset (Callithrix jacchus), non-human primate (NHP), prefrontal cortex, synapse dysfunction, ultrastructural size principle, working memoryDOI10.3389/fnagi.2023.1146245 Google Scholar Pubmed |
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Toggle | Conspecific "gaze following" in bottlenose dolphins | Animal cognition | Johnson CM, Ruiz-Mendoza C, Schoenbeck C | 2022 | 1435-9456 | |
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Publication TypeJournal ArticleAbstract“Gaze following”-when one individual witnesses another shift its orientation, and then re-orients in the same direction-has been observed in a wide range of species. Related work with dolphins has to date focused on human-dolphin interactions. In this conspecific study, we examined a group of dolphins orienting, in passing, to gateways between their pools, as opportunities for witnesses to demonstrate “gaze following”. Seven bottlenose dolphins were synchronously videotaped on six underwater cameras, for 21 h over three days, and the recordings analyzed by trained observers. The identities of all animals present, their partner state, and whether and to what degree they had altered their access to the gate (e.g., from Monocular to Binocular, or Binocular to Visio-Echoic) was recorded. Compared to animals that did not witness such a change, witnesses of an increase in access by another dolphin were significantly more likely to also act to increase their own access. We observed 460 such cases of “gaze following” in these animals. Dolphins who were partnered (showed sustained swimming within 1 body length) were significantly more likely, than non-partnered animals, to “gaze follow”. Dolphins also showed a significant tendency toward matching the kind of access they observed. No significant difference was found in the presence of animals in the back pools, during changes in orientation that were followed, versus in those that were not. These findings support adding bottlenose dolphins to the growing list of species that display conspecific “gaze following”. JournalAnimal cognitionPublication Volume25Publication Issue5Pagination1219-1229Issn1435-9456AuthorsJohnson CM, Ruiz-Mendoza C, Schoenbeck CKeywordsBottlenose dolphins, Conspecifics, Gaze followingDOI10.1007/s10071-022-01665-x Google Scholar Pubmed |
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Toggle | Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes | Cell | Russell BJ, Brown SD, Siguenza N, et al. | 2022 | 1097-4172 | |
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Publication TypeJournal ArticleAbstract
JournalCellPublication Volume185Publication Issue17Pagination3263-3277.e15Issn1097-4172AuthorsRussell BJ, Brown SD, Siguenza N, et al.KeywordsAnimals, Bacteria, Escherichia coli, Gastrointestinal Microbiome, Mice, Microbiota, TransgenesDOI10.1016/j.cell.2022.06.050 Google Scholar Pubmed |
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Toggle | Lessons from the Stories of Women in Neuroscience | J Neurosci | Sibener LJ, Kirchgessner MA, Steiner S, et al. | 2022 | 1529-2401 | |
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Publication TypeJournal ArticleAbstract
JournalJ NeurosciPublication Volume42Publication Issue24Pagination4769-4773Issn1529-2401AuthorsSibener LJ, Kirchgessner MA, Steiner S, et al.KeywordsAnxiety Disorders, Ethnicity, Female, Humans, Male, Neurosciences, Racial Groups, Self ConceptDOI10.1523/JNEUROSCI.0536-22.2022 Google Scholar Pubmed |
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Toggle | Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits. | Nature communications | Ward S, Riley C, Carey EM, et al. | 2022 | 2041-1723 | |
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Publication TypeJournal ArticleAbstractCentral to advancing our understanding of neural circuits is developing minimally invasive, multi-modal interfaces capable of simultaneously recording and modulating neural activity. Recent devices have focused on matching the mechanical compliance of tissue to reduce inflammatory responses. However, reductions in the size of multi-modal interfaces are needed to further improve biocompatibility and long-term recording capabilities. Here a multi-modal coaxial microprobe design with a minimally invasive footprint (8-14 µm diameter over millimeter lengths) that enables efficient electrical and optical interrogation of neural networks is presented. In the brain, the probes allowed robust electrical measurement and optogenetic stimulation. Scalable fabrication strategies can be used with various electrical and optical materials, making the probes highly customizable to experimental requirements, including length, diameter, and mechanical properties. Given their negligible inflammatory response, these probes promise to enable a new generation of readily tunable multi-modal devices for long-term, minimally invasive interfacing with neural circuits. JournalNature communicationsPublication Volume13Publication Issue1Pagination3286Published2022/06/07Issn2041-1723AuthorsWard S, Riley C, Carey EM, et al.DOI10.1038/s41467-022-30275-x Google Scholar Pubmed |
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Toggle | Knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3 | Elife | Li J, Pinto-Duarte A, Zander M, et al. | 2022 | 2050-084X | |
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Publication TypeJournal ArticleAbstract
JournalElifePublication Volume11Published2022/05/23Issn2050-084XAuthorsLi J, Pinto-Duarte A, Zander M, et al.KeywordsAnimals, Brain, Disease Models, Animal, DNA Methyltransferase 3A, Histone Code, Histones, Mice, Mice, Knockout, Neurons, Polycomb Repressive Complex 2, SynapsesDOI10.7554/eLife.66909 Google Scholar Pubmed |
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Toggle | Adaptive integration of self-motion and goals in posterior parietal cortex. | Cell Rep | Alexander AS, Tung JC, G Chapman W, et al. | 2022 | 2211-1247 | |
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Publication TypeJournal ArticleAbstract
JournalCell RepPublication Volume38Publication Issue10Pagination110504Issn2211-1247AuthorsAlexander AS, Tung JC, G Chapman W, et al.DOIhttp://dx.doi.org/10.1016/j.celrep.2022.110504 Google Scholar Pubmed |
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Toggle | Differential mechanisms underlie trace and delay conditioning in Drosophila. | Nature | Grover D, Chen JY, Xie J, et al. | 2022 | 1476-4687 | |
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Publication TypeJournal ArticleAbstractTwo forms of associative learning-delay conditioning and trace conditioning-have been widely investigated in humans and higher-order mammals. In delay conditioning, an unconditioned stimulus (for example, an electric shock) is introduced in the final moments of a conditioned stimulus (for example, a tone), with both ending at the same time. In trace conditioning, a ‘trace’ interval separates the conditioned stimulus and the unconditioned stimulus. Trace conditioning therefore relies on maintaining a neural representation of the conditioned stimulus after its termination (hence making distraction possible), to learn the conditioned stimulus-unconditioned stimulus contingency; this makes it more cognitively demanding than delay conditioning. Here, by combining virtual-reality behaviour with neurogenetic manipulations and in vivo two-photon brain imaging, we show that visual trace conditioning and delay conditioning in Drosophila mobilize R2 and R4m ring neurons in the ellipsoid body. In trace conditioning, calcium transients during the trace interval show increased oscillations and slower declines over repeated training, and both of these effects are sensitive to distractions. Dopaminergic activity accompanies signal persistence in ring neurons, and this is decreased by distractions solely during trace conditioning. Finally, dopamine D1-like and D2-like receptor signalling in ring neurons have different roles in delay and trace conditioning; dopamine D1-like receptor 1 mediates both forms of conditioning, whereas the dopamine D2-like receptor is involved exclusively in sustaining ring neuron activity during the trace interval of trace conditioning. These observations are similar to those previously reported in mammals during arousal, prefrontal activation and high-level cognitive learning. JournalNaturePublication Volume603Pagination302Issn1476-4687AuthorsGrover D, Chen JY, Xie J, et al.DOI10.1038/s41586-022-04433-6 Google Scholar Pubmed |
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Toggle | Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases. | Science (New York, N.Y.) | Makowski C, van der Meer D, Dong W, et al. | 2022 | 1095-9203 | |
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Publication TypeJournal ArticleAbstractTo determine the impact of genetic variants on the brain, we used genetically informed brain atlases in genome-wide association studies of regional cortical surface area and thickness in 39,898 adults and 9136 children. We uncovered 440 genome-wide significant loci in the discovery cohort and 800 from a post hoc combined meta-analysis. Loci in adulthood were largely captured in childhood, showing signatures of negative selection, and were linked to early neurodevelopment and pathways associated with neuropsychiatric risk. Opposing gradations of decreased surface area and increased thickness were associated with common inversion polymorphisms. Inferior frontal regions, encompassing Broca’s area, which is important for speech, were enriched for human-specific genomic elements. Thus, a mixed genetic landscape of conserved and human-specific features is concordant with brain hierarchy and morphogenetic gradients. JournalScience (New York, N.Y.)Publication Volume375Publication Issue6580Pagination522-528Issn1095-9203AuthorsMakowski C, van der Meer D, Dong W, et al.DOI10.1126/science.abe8457 Google Scholar Pubmed |
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Toggle | Valence opponency in peripheral olfactory processing | Proc Natl Acad Sci U S A | Wu S-T, Chen J-Y, Martin V, et al. | 2022 | 1091-6490 | |
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Publication TypeJournal ArticleAbstract
JournalProc Natl Acad Sci U S APublication Volume119Publication Issue5Issn1091-6490AuthorsWu S-T, Chen J-Y, Martin V, et al.DOI10.1073/pnas.2120134119 Google Scholar Pubmed |
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Toggle | Neurally driven synthesis of learned, complex vocalizations | Current Biology | Arneodo EM, Chen S, Brown DE, et al. | 2021 | 0960-9822 | |
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Publication TypeCurrent BiologyAbstract
JournalCurrent BiologyPublication Volume31Publication Issue15PaginationP3419-3425.E5Issn0960-9822AuthorsArneodo EM, Chen S, Brown DE, et al.DOI10.1016/j.cub.2021.05.035 Google Scholar Pubmed |
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Toggle | Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. | Elife | Li Y, Ritchie EM, Steinke CL, et al. | 2021 | 2050-084X | |
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Publication TypeJournal ArticleAbstract
JournalElifePublication Volume10Published2021/01/21Issn2050-084XAuthorsLi Y, Ritchie EM, Steinke CL, et al.DOI10.7554/eLife.63509 Google Scholar Pubmed |
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Toggle | A modeling framework for adaptive lifelong learning with transfer and savings through gating in the prefrontal cortex | Proceedings of the National Academy of Sciences | Tsuda B, Tye KM, Siegelmann HT, et al. | 2020 | 0027-8424 | |
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Publication TypeJournal ArticleAbstract
JournalProceedings of the National Academy of SciencesPublication Volume117Pagination29872–29882Published2020/11/24Issn0027-8424AuthorsTsuda B, Tye KM, Siegelmann HT, et al.DOI10.1073/pnas.2009591117 Google Scholar Pubmed |
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Toggle | Massively Parallel Causal Inference of Whole Brain Dynamics at Single Neuron Resolution | 2020 IEEE 26th International Conference on Parallel and Distributed Systems (ICPADS) | Watanakeesuntorn W, Takahashi K, Ichikawa K, et al. | 2020 | ||
Publication TypeConference PaperAbstract
Journal2020 IEEE 26th International Conference on Parallel and Distributed Systems (ICPADS)AuthorsWatanakeesuntorn W, Takahashi K, Ichikawa K, et al.DOI10.1109/ICPADS51040.2020.00035 Google Scholar Pubmed |
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Toggle | Imaging brain activity during complex social behaviors in Drosophila with Flyception2. | Nature communications | Grover D, Katsuki T, Li J, et al. | 2020 | 2041-1723 | |
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Publication TypeJournal ArticleAbstractOptical in vivo recordings from freely walking Drosophila are currently possible only for limited behaviors. Here, we expand the range of accessible behaviors with a retroreflective marker-based tracking and ratiometric brain imaging system, permitting brain activity imaging even in copulating male flies. We discover that P1 neurons, active during courtship, are inactive during copulation, whereas GABAergic mAL neurons remain active during copulation, suggesting a countervailing role of mAL in opposing P1 activity during mating. JournalNature communicationsPublication Volume11Publication Issue1Pagination623Published2020/01/30Issn2041-1723AuthorsGrover D, Katsuki T, Li J, et al.DOI10.1038/s41467-020-14487-7 Google Scholar Pubmed |
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Toggle | Nicotine-induced dopamine plasticity: a gateway to neurotransmitter replacement? | Neural regeneration research | Lai IC, Dulcis D | 2020 | 1673-5374 | |
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Publication TypeJournal ArticleAbstractJournalNeural regeneration researchPublication Volume15Publication Issue1Pagination73-74Issn1673-5374AuthorsLai IC, Dulcis DDOI10.4103/1673-5374.264451 Google Scholar Pubmed |
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Toggle | Impairments in remote memory caused by the lack of Type 2 IP3 receptors | Glia | Pinto-Duarte A, Roberts AJ, Ouyang K, et al. | 2019 | 1098-1136 | |
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Publication TypeJournal ArticleAbstract
JournalGliaPublication Volume67Publication Issue10Pagination1976-1989Issn1098-1136AuthorsPinto-Duarte A, Roberts AJ, Ouyang K, et al.Keywordsastrocyte, Behavior, Ca2+ signaling, long-term memory, synaptic plasticityDOI10.1002/glia.23679 Google Scholar Pubmed |
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Toggle | Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. | iScience | Scott J, Thakar S, Mao Y, et al. | 2019 | 2589-0042 | |
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Publication TypeJournal ArticleAbstractNormal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein kinase Cs (aPKCs). A planar cell polarity protein, Vangl2, which inhibits synapse formation, was decreased in synaptosome fractions of cultured cortical neurons from Lgl1 knockout embryos. Conditional knockout of Lgl1 in pyramidal neurons led to reduction of AMPA/NMDA ratio and impaired plasticity. Lgl1 is frequently deleted in Smith-Magenis syndrome (SMS). Lgl1 conditional knockout led to increased locomotion, impaired novel object recognition and social interaction. Lgl1+/- animals also showed increased synapse numbers, defects in open field and social interaction, as well as stereotyped repetitive behavior. Social interaction in Lgl1+/- could be rescued by NMDA antagonists. Our findings reveal a role of apical-basal polarity proteins in glutamatergic synapse development and function and also suggest a potential treatment for SMS patients with Lgl1 deletion. JournaliSciencePublication Volume20Pagination25-41Issn2589-0042AuthorsScott J, Thakar S, Mao Y, et al.KeywordsBiological Sciences, Cell Biology, Cellular Neuroscience, NeuroscienceDOI10.1016/j.isci.2019.09.005 Google Scholar Pubmed |
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Toggle | Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption | Biol Psychiatry | Romoli B, Lozada AF, Sandoval IM, et al. | 2019 | 1873-2402 | |
PubMed Record
Publication TypeJournal ArticleAbstractBACKGROUND: Nicotine intake induces addiction through neuroplasticity of the reward circuitry, altering the activity of dopaminergic neurons of the ventral tegmental area. Prior work demonstrated that altered circuit activity can change neurotransmitter expression in the developing and adult brain. Here we investigated the effects of neonatal nicotine exposure on the dopaminergic system and nicotine consumption in adulthood. METHODS: Male and female mice were used for two-bottle-choice test, progressive ratio breakpoint test, immunohistochemistry, RNAscope, quantitative polymerase chain reaction, calcium imaging, and DREADD (designer receptor exclusively activated by designer drugs)-mediated chemogenic activation/inhibition experiments. RESULTS: Neonatal nicotine exposure potentiates drug preference in adult mice, induces alterations in calcium spike activity of midbrain neurons, and increases the number of dopamine-expressing neurons in the ventral tegmental area. Specifically, glutamatergic neurons are first primed to express transcription factor Nurr1, then acquire the dopaminergic phenotype following nicotine re-exposure in adulthood. Enhanced neuronal activity combined with Nurr1 expression is both necessary and sufficient for the nicotine-mediated neurotransmitter plasticity to occur. CONCLUSIONS: Our findings illuminate a new mechanism of neuroplasticity by which early nicotine exposure primes the reward system to display increased susceptibility to drug consumption in adulthood. JournalBiol PsychiatryPublication Volume86Publication Issue5Pagination344-355Issn1873-2402AuthorsRomoli B, Lozada AF, Sandoval IM, et al.DOI10.1016/j.biopsych.2019.04.019 Google Scholar Pubmed |
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Toggle | Scaling Principles of Distributed Circuits | Curr Biol | Srinivasan S, Stevens CF | 2019 | 1879-0445 | |
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Publication TypeJournal ArticleAbstract
JournalCurr BiolPublication Volume29Publication Issue15Pagination2533-2540.e7Issn1879-0445AuthorsSrinivasan S, Stevens CFDOI10.1016/j.cub.2019.06.046 Google Scholar Pubmed |
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Toggle | Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. | Nature communications | Zhang Y, Tsang TK, Bushong EA, et al. | 2019 | 2041-1723 | |
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Publication TypeJournal ArticleAbstractIn the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled by the same tungsten electrode to demonstrate that direct electrical (“ephaptic”) interactions mediate lateral inhibition between ORNs. Intriguingly, within individual sensilla, we find that ephaptic lateral inhibition is asymmetric such that one ORN exerts greater influence onto its neighbor. Serial block-face scanning electron microscopy of genetically identified ORNs and circuit modeling indicate that asymmetric lateral inhibition reflects a surprisingly simple mechanism: the physically larger ORN in a pair corresponds to the dominant neuron in ephaptic interactions. Thus, morphometric differences between compartmentalized ORNs account for highly specialized inhibitory interactions that govern information processing at the earliest stages of olfactory coding. JournalNature communicationsPublication Volume10Publication Issue1Pagination1560Published2019/04/05Issn2041-1723AuthorsZhang Y, Tsang TK, Bushong EA, et al.DOI10.1038/s41467-019-09346-z Google Scholar Pubmed |
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Toggle | Fast near-whole-brain imaging in adult Drosophila during responses to stimuli and behavior. | PLoS biology | Aimon S, Katsuki T, Jia T, et al. | 2019 | 1545-7885 | |
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Publication TypeJournal ArticleAbstractWhole-brain recordings give us a global perspective of the brain in action. In this study, we describe a method using light field microscopy to record near-whole brain calcium and voltage activity at high speed in behaving adult flies. We first obtained global activity maps for various stimuli and behaviors. Notably, we found that brain activity increased on a global scale when the fly walked but not when it groomed. This global increase with walking was particularly strong in dopamine neurons. Second, we extracted maps of spatially distinct sources of activity as well as their time series using principal component analysis and independent component analysis. The characteristic shapes in the maps matched the anatomy of subneuropil regions and, in some cases, a specific neuron type. Brain structures that responded to light and odor were consistent with previous reports, confirming the new technique’s validity. We also observed previously uncharacterized behavior-related activity as well as patterns of spontaneous voltage activity. JournalPLoS biologyPublication Volume17Publication Issue2Paginatione2006732Published2019/02/15Issn1545-7885AuthorsAimon S, Katsuki T, Jia T, et al.DOI10.1371/journal.pbio.2006732 Google Scholar Pubmed |
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Toggle | Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice | Transl Psychiatry | Moore SM, Seidman JS, Ellegood J, et al. | 2019 | 2158-3188 | |
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Publication TypeJournal ArticleAbstract
JournalTransl PsychiatryPublication Volume9Publication Issue1Pagination24Published2019/01/07Issn2158-3188AuthorsMoore SM, Seidman JS, Ellegood J, et al.KeywordsAnimals, Autism Spectrum Disorder, Behavior, Animal, Brain, Female, Genetic Predisposition to Disease, Haploinsufficiency, Heterozygote, Magnetic Resonance Imaging, Male, Methyltransferases, Mice, Mice, Knockout, Mutation, NeuronsDOI10.1038/s41398-018-0344-y Google Scholar Pubmed |
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Toggle | Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia | Nat Commun | Fan CChieh, McGrath JJ, Appadurai V, et al. | 2018 | 2041-1723 | |
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Publication TypeJournal ArticleAbstract
JournalNat CommunPublication Volume9Publication Issue1Pagination5296Issn2041-1723AuthorsFan CChieh, McGrath JJ, Appadurai V, et al.KeywordsChromosome Mapping, Denmark, Environment, Genetic Predisposition to Disease, Geography, Humans, Proof of Concept Study, Risk Factors, SchizophreniaDOI10.1038/s41467-018-07708-7 Google Scholar Pubmed |
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Toggle | A neural data structure for novelty detection. | Proceedings of the National Academy of Sciences of the United States of America | Dasgupta S, Sheehan TC, Stevens CF, et al. | 2018 | 1091-6490 | |
PubMed Record
Publication TypeJournal ArticleAbstractNovelty detection is a fundamental biological problem that organisms must solve to determine whether a given stimulus departs from those previously experienced. In computer science, this problem is solved efficiently using a data structure called a Bloom filter. We found that the fruit fly olfactory circuit evolved a variant of a Bloom filter to assess the novelty of odors. Compared with a traditional Bloom filter, the fly adjusts novelty responses based on two additional features: the similarity of an odor to previously experienced odors and the time elapsed since the odor was last experienced. We elaborate and validate a framework to predict novelty responses of fruit flies to given pairs of odors. We also translate insights from the fly circuit to develop a class of distance- and time-sensitive Bloom filters that outperform prior filters when evaluated on several biological and computational datasets. Overall, our work illuminates the algorithmic basis of an important neurobiological problem and offers strategies for novelty detection in computational systems. JournalProceedings of the National Academy of Sciences of the United States of AmericaPublication Volume115Publication Issue51Pagination13093-13098Issn1091-6490AuthorsDasgupta S, Sheehan TC, Stevens CF, et al.KeywordsBloom filters, computer science, data structures, fly olfactory circuit, novelty detectionDOI10.1073/pnas.1814448115 Google Scholar Pubmed |
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Toggle | The distributed circuit within the piriform cortex makes odor discrimination robust | J Comp Neurol | Srinivasan S, Stevens CF | 2018 | 1096-9861 | |
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Publication TypeJournal ArticleAbstract
JournalJ Comp NeurolPublication Volume526Publication Issue17Pagination2725-2743Issn1096-9861AuthorsSrinivasan S, Stevens CFDOI10.1002/cne.24492 Google Scholar Pubmed |
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Toggle | Deep(er) Learning | J Neurosci | Srinivasan S, Greenspan RJ, Stevens CF, et al. | 2018 | 1529-2401 | |
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Publication TypeJournal ArticleAbstract
JournalJ NeurosciPublication Volume38Publication Issue34Pagination7365-7374Published2018/08/22Issn1529-2401AuthorsSrinivasan S, Greenspan RJ, Stevens CF, et al.DOI10.1523/JNEUROSCI.0153-18.2018 Google Scholar Pubmed |
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Toggle | Multiplexed oscillations and phase rate coding in the basal forebrain | Sci Adv | Tingley D, Alexander AS, Quinn LK, et al. | 2018 | 2375-2548 | |
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Publication TypeJournal ArticleAbstract
JournalSci AdvPublication Volume4Publication Issue8Paginationeaar3230Published2018/08/08Issn2375-2548AuthorsTingley D, Alexander AS, Quinn LK, et al.KeywordsAnimals, Basal Forebrain, Male, Models, Neurological, Neurons, Rats, Rats, Long-Evans, Space Perception, Theta RhythmDOI10.1126/sciadv.aar3230 Google Scholar Pubmed |
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Toggle | Single-Trial EEG Analysis Predicts Memory Retrieval and Reveals Source-Dependent Differences | Front Hum Neurosci | Noh E, Liao K, Mollison MV, et al. | 2018 | 1662-5161 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalFront Hum NeurosciPublication Volume12Publication Issue258Issn1662-5161AuthorsNoh E, Liao K, Mollison MV, et al.DOI10.3389/fnhum.2018.00258 Google Scholar Pubmed |
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Toggle | High-quality ultrastructural preservation using cryofixation for 3D electron microscopy of genetically labeled tissues | Elife | Tsang TKi, Bushong EA, Boassa D, et al. | 2018 | 2050-084X | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalElifePublication Volume7Issn2050-084XAuthorsTsang TKi, Bushong EA, Boassa D, et al.KeywordsAnimal Structures, Animals, Brain, Cryopreservation, Drosophila, Imaging, Three-Dimensional, Mice, Microscopy, Electron, Scanning, Sense OrgansDOI10.7554/eLife.35524 Google Scholar Pubmed |
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Toggle | How struggling adult readers use contextual information when comprehending speech: Evidence from event-related potentials | Int J Psychophysiol | Ng S, Payne BR, Stine-Morrow EAL, et al. | 2018 | 1872-7697 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalInt J PsychophysiolPublication Volume125Pagination1-9Issn1872-7697AuthorsNg S, Payne BR, Stine-Morrow EAL, et al.KeywordsAdult, Aged, Brain Mapping, Comprehension, Electroencephalography, Evoked Potentials, Female, Humans, Literacy, Male, Middle Aged, Neuropsychological Tests, Photic Stimulation, Reaction Time, Reading, Speech, Young AdultDOI10.1016/j.ijpsycho.2018.01.013 Google Scholar Pubmed |
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Toggle | Biosynthesis of Orthogonal Molecules Using Ferredoxin and Ferredoxin-NADP+ Reductase Systems Enables Genetically Encoded PhyB Optogenetics | ACS Synth Biol | Kyriakakis P, Catanho M, Hoffner N, et al. | 2018 | 2161-5063 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalACS Synth BiolIssn2161-5063AuthorsKyriakakis P, Catanho M, Hoffner N, et al.DOI10.1021/acssynbio.7b00413 Google Scholar Pubmed |
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Toggle | Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study | Int J Geriatr Psychiatry | Dev SI, Moore RC, Soontornniyomkij B, et al. | 2017 | 1099-1166 | |
PubMed Record
Publication TypeJournal ArticleAbstractOBJECTIVE: Peripheral inflammation has been associated with adverse effects on cognition and brain structure in late life, a process called ‘inflammaging.’ Identifying biomarkers of preclinical cognitive decline is critical in the development of preventative therapies, and peripheral inflammation may be able to serve as an indicator of cognitive decline. However, little is known regarding the relationship between peripheral inflammation and brain structure and function among older adults. METHODS: Twenty-four older adults (mean age = 78) underwent a functional magnetic resonance imaging (fMRI) resting state functional connectivity scan, and a subset (n = 14) completed the n-Back working memory task in the scanner. All participants completed a blood draw, and inflammation was measured with interleukin 6 (IL-6) and C-Reactive Protein (CRP). RESULTS: Surprisingly, age was unrelated to measures of inflammation (IL-6, CRP) or brain function (default mode network (DMN) connectivity; working memory performance; blood oxygenation level dependent (BOLD) activation with higher working memory load). However, lower functional connectivity between the left parietal seed and all other DMN regions was associated with higher levels of IL-6 and CRP. Additionally, greater plasma concentration of IL-6 was associated with lower BOLD activation in the left middle frontal gyrus in response to increased working memory load. CONCLUSIONS: These preliminary findings support the importance of IL-6 and CRP in brain function among older adults. Frontal and parietal regions may be particularly sensitive to the effects of inflammation. Additionally, these findings provide preliminary evidence of inflammatory contributions to level of neural activity, even after accounting for vascular risk factors. JournalInt J Geriatr PsychiatryPublication Volume32Publication Issue3Pagination341-349Published2017/03/03Issn1099-1166AuthorsDev SI, Moore RC, Soontornniyomkij B, et al.KeywordsAged, Brain Mapping, C-Reactive Protein, Cognition, Cognitive Dysfunction, Female, Frontal Lobe, Humans, Inflammation, Interleukin-6, Magnetic Resonance Imaging, Male, Memory, Short-Term, Parietal Lobe, RestDOI10.1002/gps.4482 Google Scholar Pubmed |
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Toggle | Subiculum neurons map the current axis of travel | Nat Neurosci | Olson JM, Tongprasearth K, Nitz DA | 2017 | 1546-1726 | |
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Publication TypeJournal ArticleAbstract
JournalNat NeurosciPublication Volume20Publication Issue2Pagination170-172Published2017/02/02Issn1546-1726AuthorsOlson JM, Tongprasearth K, Nitz DAKeywordsAction Potentials, Animals, Brain Mapping, Hippocampus, Male, Neurons, Orientation, Rats, Sprague-Dawley, Space PerceptionDOI10.1038/nn.4464 Google Scholar Pubmed |
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Toggle | Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation | Proc Natl Acad Sci U S A | Thakar S, Wang L, Yu T, et al. | 2017 | 1091-6490 | |
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Publication TypeJournal ArticleAbstract
JournalProc Natl Acad Sci U S APublication Volume114Publication Issue4PaginationE610-E618Published2017/01/24Issn1091-6490AuthorsThakar S, Wang L, Yu T, et al.KeywordsAnimals, Behavior, Animal, Cadherins, Cell Polarity, Cells, Cultured, Excitatory Postsynaptic Potentials, Glutamic Acid, Hippocampus, Locomotion, Male, Maze Learning, Mice, Knockout, Nerve Tissue Proteins, Pyramidal Cells, Receptors, Cell Surface, Synapses, Wnt-5a ProteinDOI10.1073/pnas.1612062114 Google Scholar Pubmed |
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Toggle | Swimming Microrobot Optical Nanoscopy | Nano Lett | Li J, Liu W, Li T, et al. | 2016 | 1530-6992 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNano LettPublication Volume16Publication Issue10Pagination6604-6609Published2016/10/12Issn1530-6992AuthorsLi J, Liu W, Li T, et al.DOI10.1021/acs.nanolett.6b03303 Google Scholar Pubmed |
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Toggle | Optogenetic manipulation of neural circuits in awake marmosets | J Neurophysiol | MacDougall M, Nummela SU, Coop S, et al. | 2016 | 1522-1598 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ NeurophysiolPublication Volume116Publication Issue3Pagination1286-94Published2016/09/01Issn1522-1598AuthorsMacDougall M, Nummela SU, Coop S, et al.KeywordsAction Potentials, Animals, Bacterial Proteins, Brain, Callithrix, Dependovirus, Female, Genetic Vectors, Luminescent Proteins, Microelectrodes, Models, Animal, Neural Pathways, Neurons, Optogenetics, Photic Stimulation, Rhodopsin, Serogroup, WakefulnessDOI10.1152/jn.00197.2016 Google Scholar Pubmed |
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Toggle | Flyception: imaging brain activity in freely walking fruit flies | Nat Methods | Grover D, Katsuki T, Greenspan RJ | 2016 | 1548-7105 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNat MethodsPublication Volume13Publication Issue7Pagination567-572Published2016/07/07Issn1548-7105AuthorsGrover D, Katsuki T, Greenspan RJDOI10.1038/nmeth.3866 Google Scholar Pubmed |
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Toggle | Temporal and spatial tuning of dorsal lateral geniculate nucleus neurons in unanesthetized rats | J Neurophysiol | Sriram B, Meier PM, Reinagel P | 2016 | 1522-1598 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ NeurophysiolPublication Volume115Publication Issue5Pagination2658-71Published2016/06/01Issn1522-1598AuthorsSriram B, Meier PM, Reinagel PKeywordsAnimals, Evoked Potentials, Visual, Geniculate Bodies, Male, Neurons, Rats, Rats, Long-Evans, WakefulnessDOI10.1152/jn.00812.2014 Google Scholar Pubmed |
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Toggle | Marmosets: A Neuroscientific Model of Human Social Behavior | Neuron | Miller CT, Freiwald WA, Leopold DA, et al. | 2016 | 1097-4199 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNeuronPublication Volume90Publication Issue2Pagination219-233Issn1097-4199AuthorsMiller CT, Freiwald WA, Leopold DA, et al.KeywordsAnimals, Animals, Genetically Modified, Brain, Callithrix, Cognition, Disease Models, Animal, Eye Movements, Haplorhini, Humans, Models, Animal, Rodentia, Social Behavior, Social Behavior Disorders, Vocalization, AnimalDOI10.1016/j.neuron.2016.03.018 Google Scholar Pubmed |
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Toggle | Primate-specific ORF0 contributes to retrotransposon-mediated diversity. | Cell | Denli AM, Narvaiza I, Kerman BE, et al. | 2015 | 1097-4172 | |
PubMed Record
Publication TypeJournal ArticleAbstractLINE-1 retrotransposons are fast-evolving mobile genetic entities that play roles in gene regulation, pathological conditions, and evolution. Here, we show that the primate LINE-1 5’UTR contains a primate-specific open reading frame (ORF) in the antisense orientation that we named ORF0. The gene product of this ORF localizes to promyelocytic leukemia-adjacent nuclear bodies. ORF0 is present in more than 3,000 loci across human and chimpanzee genomes and has a promoter and a conserved strong Kozak sequence that supports translation. By virtue of containing two splice donor sites, ORF0 can also form fusion proteins with proximal exons. ORF0 transcripts are readily detected in induced pluripotent stem (iPS) cells from both primate species. Capped and polyadenylated ORF0 mRNAs are present in the cytoplasm, and endogenous ORF0 peptides are identified upon proteomic analysis. Finally, ORF0 enhances LINE-1 mobility. Taken together, these results suggest a role for ORF0 in retrotransposon-mediated diversity. JournalCellPublication Volume163Publication Issue3Pagination583-93Issn1097-4172AuthorsDenli AM, Narvaiza I, Kerman BE, et al.DOI10.1016/j.cell.2015.09.025 Google Scholar Pubmed |
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Toggle | Motion dependence of smooth pursuit eye movements in the marmoset | J Neurophysiol | Mitchell JF, Priebe NJ, Miller CT | 2015 | 1522-1598 | |
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Publication TypeJournal ArticleAbstract
JournalJ NeurophysiolPublication Volume113Publication Issue10Pagination3954-60Issn1522-1598AuthorsMitchell JF, Priebe NJ, Miller CTKeywordsAcceleration, Animals, Callithrix, Motion, Motion Perception, Photic Stimulation, Pursuit, Smooth, Retina, Visual FieldsDOI10.1152/jn.00197.2015 Google Scholar Pubmed |
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Toggle | Distinct neural correlates of emotional and cognitive empathy in older adults | Psychiatry Res | Moore RC, Dev SI, Jeste DV, et al. | 2015 | 1872-7123 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalPsychiatry ResPublication Volume232Publication Issue1Pagination42-50Published2015/04/30Issn1872-7123AuthorsMoore RC, Dev SI, Jeste DV, et al.KeywordsAffect, Aged, Aged, 80 and over, Aging, Brain, Brain Mapping, Cognition, Emotions, Empathy, Female, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Social Behavior, Social PerceptionDOI10.1016/j.pscychresns.2014.10.016 Google Scholar Pubmed |
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Toggle | Mean signal and response time influences on multivoxel signals of contextual retrieval in the medial temporal lobe | Brain Behav | Reas ET, Brewer JB | 2015 | 2162-3279 | |
PubMed Record
Publication TypeJournal ArticleAbstractINTRODUCTION: The medial temporal lobe supports integrating the “what,” “where,” and “when” of an experience into a unified memory. However, it remains unclear how representations of these contextual features are neurally encoded and distributed across medial temporal lobe subregions. METHODS: This study conducted functional magnetic resonance imaging of the medial temporal lobe, while participants retrieved pair, spatial, and temporal source memories. Multivoxel classifiers were trained to distinguish between retrieval conditions before and after correction for mean signal and response times, to more thoroughly characterize the multivoxel signal associated with memory context. RESULTS: Activity in perirhinal and parahippocampal cortex dissociated between memory for associated items and memory for their spatiotemporal context, and hippocampal activity was linked to memory for spatial context. However, perirhinal and hippocampal classifiers were, respectively, driven by effects of mean signal amplitude and task difficulty, whereas the parahippocampal classifier survived correction for these effects. CONCLUSION: These findings demonstrate dissociable coding mechanisms for episodic memory context across the medial temporal lobe, and further highlight a critical distinction between multivoxel representations driven by spatially distributed activity patterns, and those driven by the regional signal. JournalBrain BehavPublication Volume5Publication Issue2Paginatione00302Published2015/02/06Issn2162-3279AuthorsReas ET, Brewer JBKeywordsAdult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Photic Stimulation, Temporal Lobe, Young AdultDOI10.1002/brb3.302 Google Scholar Pubmed |
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Toggle | Children's Task-Switching Efficiency: Missing Our Cue? | Journal of Cognition and Development | Holt AE, Deák G | 2015 | 1532-7647 | |
Publication TypeJournal ArticleAbstractIn simple rule-switching tests, 3- and 4-year-olds can follow each of two sorting rules but sometimes make perseverative errors when switching. Older children make few errors but respond slowly when switching. These age-related changes might reflect the maturation of executive functions (e.g., inhibition). However, they might also reflect children’s ability to use task cues. Cue-processing difficulties predict switch costs in adult task switching (Logan & Schneider, 200748. Logan, G. D., & Schneider, D. W. (2007). Task switching versus cue switching: Using transition cuing to disentangle sequential effects in task-switching performance. Journal of Experimental Psychology: Learning, Memory, and Cognition, 33, 370–378.View all references). It is unknown whether they explain children’s task-switching errors or slowing. The current study tested whether inhibition, cue interpretation, or both predict 3- to 6-year-old children’s switch-related errors (Experiment 1) and slowing (Experiment 2). Children performed a computerized task-switching test in which most trials were preceded by an audiovisual cue that instructed them to switch rules, or to stay—that is, continue using the current rule. Interspersed control trials used no cue. In Experiment 1, 3- and 4-year-olds made as many errors on cued stay trials as on cued switch trials; however, children were significantly more accurate on uncued stay trials. The presence of cues, not switching demands, predicted errors. Accuracy was predicted by children’s speed in a simpler task in which children matched stimuli on only one dimension (shape or color), with no stimulus conflict or rule switches. Additional variance was predicted by an unrelated measure of processing speed. In Experiment 2, switch costs in 4.5- to 6-year-olds were similarly predicted by speed in the simpler unidimensional matching task.
JournalJournal of Cognition and DevelopmentPublication Volume16Publication Issue2Pagination261-285Issn1532-7647AuthorsHolt AE, Deák GDOI10.1080/15248372.2013.833921 Google Scholar Pubmed |
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Toggle | From suffering to caring: a model of differences among older adults in levels of compassion | Int J Geriatr Psychiatry | Moore RC, Martin A'verriaSirkin, Kaup AR, et al. | 2015 | 1099-1166 | |
PubMed Record
Publication TypeJournal ArticleAbstractOBJECTIVE: Compassion is an important contributor to pro-social behavior and maintenance of interpersonal relationships, yet little is known about what factors influence compassion in late life. The aim of this study was to test theories about how past and current stressors and emotional functioning, resilience, and demographic indicators of life experiences are related to compassion among older adults. METHODS: One thousand and six older adults (50-99 years) completed a comprehensive survey including self-report measures of compassion, resilience, past and present stress, and emotional functioning (i.e., stressful life events, perceived stress, and current and prior depression and anxiety), and demographic information. The sample was randomly split, and exploratory and confirmatory regression analyses were conducted testing hypothesized relationships with compassion. RESULTS: Exploratory stepwise regression analysis (n = 650) indicated that participants who reported higher levels of compassion were more likely to be female, not currently in a married/married-like relationship, reported higher resilience levels, and had experienced more significant life events. Age, income level, past and current mental distress, and interactions between resilience and other predictors were not significantly related to compassion. The associations between greater self-reported compassion and being female, having greater resilience, and having experienced more significant life events were supported by a confirmatory stepwise regression analysis (n = 356). CONCLUSIONS: Older women report more compassion than older men. Resilience and significant life events, independently, also appear to facilitate a desire to help others, while current stress and past and present emotional functioning are less relevant. Specificity of findings to older adults is not yet known. JournalInt J Geriatr PsychiatryPublication Volume30Publication Issue2Pagination185-91Issn1099-1166AuthorsMoore RC, Martin A'verriaSirkin, Kaup AR, et al.KeywordsAge Factors, Aged, Aged, 80 and over, Empathy, Female, Humans, Life Change Events, Male, Marital Status, Middle Aged, Regression Analysis, Resilience, Psychological, Sex Factors, Socioeconomic FactorsDOI10.1002/gps.4123 Google Scholar Pubmed |
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Toggle | Tool morphology constrains the effects of tool use on body representations | J Exp Psychol Hum Percept Perform | Miller LE, Longo MR, Saygin AP | 2014 | 1939-1277 | |
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Publication TypeJournal ArticleAbstract
JournalJ Exp Psychol Hum Percept PerformPublication Volume40Publication Issue6Pagination2143-53Issn1939-1277AuthorsMiller LE, Longo MR, Saygin APKeywordsAdolescent, Adult, Body Image, Discrimination (Psychology), Distance Perception, Female, Form Perception, Humans, Judgment, Male, Size Perception, Tool Use Behavior, Touch Perception, Young AdultDOI10.1037/a0037777 Google Scholar Pubmed |
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Toggle | Inhibitory motor control based on complex stopping goals relies on the same brain network as simple stopping | Neuroimage | Wessel JR, Aron AR | 2014 | 1095-9572 | |
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Publication TypeJournal ArticleAbstract
JournalNeuroimagePublication Volume103Pagination225-34Issn1095-9572AuthorsWessel JR, Aron ARKeywordsAdolescent, Adult, Brain, Brain Mapping, Electroencephalography, Female, Goals, Humans, Inhibition (Psychology), Male, Psychomotor Performance, Reaction Time, Young AdultDOI10.1016/j.neuroimage.2014.09.048 Google Scholar Pubmed |
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Toggle | Gamma band activity and the P3 reflect post-perceptual processes, not visual awareness | Neuroimage | Pitts MA, Padwal J, Fennelly D, et al. | 2014 | 1095-9572 | |
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Publication TypeJournal ArticleAbstract
JournalNeuroimagePublication Volume101Pagination337-350Issn1095-9572AuthorsPitts MA, Padwal J, Fennelly D, et al.KeywordsAdult, Attention, Awareness, Consciousness, Electroencephalography, Event-Related Potentials, P300, Female, Gamma Rhythm, Humans, Male, Psychomotor Performance, Visual Perception, Young AdultDOI10.1016/j.neuroimage.2014.07.024 Google Scholar Pubmed |
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Toggle | Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex | Front Cell Neurosci | Biane J, Conner JM, Tuszynski MH | 2014 | 1662-5102 | |
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Publication TypeJournal ArticleAbstract
JournalFront Cell NeurosciPublication Volume8Publication Issue220Issn1662-5102AuthorsBiane J, Conner JM, Tuszynski MHDOI10.3389/fncel.2014.00220 Google Scholar Pubmed |
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Toggle | Speech-specific tuning of neurons in human superior temporal gyrus | Cereb Cortex | Chan AM, Dykstra AR, Jayaram V, et al. | 2014 | 1460-2199 | |
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Publication TypeJournal ArticleAbstract
JournalCereb CortexPublication Volume24Publication Issue10Pagination2679-93Issn1460-2199AuthorsChan AM, Dykstra AR, Jayaram V, et al.KeywordsAcoustic Stimulation, Adult, Humans, Male, Neurons, Phonetics, Speech Perception, Temporal LobeDOI10.1093/cercor/bht127 Google Scholar Pubmed |
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Toggle | Neural language processing in adolescent first-language learners | Cereb Cortex | Ramirez NFerjan, Leonard MK, Torres C, et al. | 2014 | 1460-2199 | |
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Publication TypeJournal ArticleAbstract
JournalCereb CortexPublication Volume24Publication Issue10Pagination2772-83Issn1460-2199AuthorsRamirez NFerjan, Leonard MK, Torres C, et al.KeywordsAdolescent, Adult, Age Factors, Cerebral Cortex, Critical Period (Psychology), Deafness, Female, Functional Laterality, Humans, Language Development, Learning, Magnetoencephalography, Male, Semantics, Sign Language, Young AdultDOI10.1093/cercor/bht137 Google Scholar Pubmed |
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Toggle | Atypical right hemisphere specialization for object representations in an adolescent with specific language impairment | Front Hum Neurosci | Brown TT, Erhart M, Avesar D, et al. | 2014 | 1662-5161 | |
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Publication TypeJournal ArticleAbstract
JournalFront Hum NeurosciPublication Volume8Publication Issue82Issn1662-5161AuthorsBrown TT, Erhart M, Avesar D, et al.DOI10.3389/fnhum.2014.00082 Google Scholar Pubmed |
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Toggle | Covariate-modulated local false discovery rate for genome-wide association studies | Bioinformatics | Zablocki RW, Schork AJ, Levine RA, et al. | 2014 | 1367-4811 | |
PubMed Record
Publication TypeJournal ArticleAbstractMOTIVATION: Genome-wide association studies (GWAS) have largely failed to identify most of the genetic basis of highly heritable diseases and complex traits. Recent work has suggested this could be because many genetic variants, each with individually small effects, compose their genetic architecture, limiting the power of GWAS, given currently obtainable sample sizes. In this scenario, Bonferroni-derived thresholds are severely underpowered to detect the vast majority of associations. Local false discovery rate (fdr) methods provide more power to detect non-null associations, but implicit assumptions about the exchangeability of single nucleotide polymorphisms (SNPs) limit their ability to discover non-null loci. METHODS: We propose a novel covariate-modulated local false discovery rate (cmfdr) that incorporates prior information about gene element-based functional annotations of SNPs, so that SNPs from categories enriched for non-null associations have a lower fdr for a given value of a test statistic than SNPs in unenriched categories. This readjustment of fdr based on functional annotations is achieved empirically by fitting a covariate-modulated parametric two-group mixture model. The proposed cmfdr methodology is applied to a large Crohn’s disease GWAS. RESULTS: Use of cmfdr dramatically improves power, e.g. increasing the number of loci declared significant at the 0.05 fdr level by a factor of 5.4. We also demonstrate that SNPs were declared significant using cmfdr compared with usual fdr replicate in much higher numbers, while maintaining similar replication rates for a given fdr cutoff in de novo samples, using the eight Crohn’s disease substudies as independent training and test datasets. Availability an implementation: https://sites.google.com/site/covmodfdr/ CONTACT: : wes.stat@gmail.com SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. JournalBioinformaticsPublication Volume30Publication Issue15Pagination2098-104Published2014/08/01Issn1367-4811AuthorsZablocki RW, Schork AJ, Levine RA, et al.KeywordsAnalysis of Variance, Bayes Theorem, Computational Biology, False Positive Reactions, Genome-Wide Association Study, Humans, Polymorphism, Single NucleotideDOI10.1093/bioinformatics/btu145 Google Scholar Pubmed |
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Toggle | Age-related changes in tissue signal properties within cortical areas important for word understanding in 12- to 19-month-old infants | Cereb Cortex | Travis KE, Curran MM, Torres C, et al. | 2014 | 1460-2199 | |
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Publication TypeJournal ArticleAbstract
JournalCereb CortexPublication Volume24Publication Issue7Pagination1948-55Published2014/07/07Issn1460-2199AuthorsTravis KE, Curran MM, Torres C, et al.KeywordsAging, Brain Mapping, Cerebral Cortex, Comprehension, Female, Humans, Image Processing, Computer-Assisted, Infant, Language Development, Magnetic Resonance Imaging, Male, VocabularyDOI10.1093/cercor/bht052 Google Scholar Pubmed |
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Toggle | Sparse and distributed coding of episodic memory in neurons of the human hippocampus | Proc Natl Acad Sci U S A | Wixted JT, Squire LR, Jang Y, et al. | 2014 | 1091-6490 | |
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Publication TypeJournal ArticleAbstract
JournalProc Natl Acad Sci U S APublication Volume111Publication Issue6Pagination9621-6Published2014/07/01Issn1091-6490AuthorsWixted JT, Squire LR, Jang Y, et al.KeywordsEpilepsy, Hippocampus, Humans, Memory, Episodic, Models, Neurological, Neurophysiological Monitoring, Neuropsychological TestsDOI10.1073/pnas.1408365111 Google Scholar Pubmed |
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Toggle | Changes in GABA and glutamate concentrations during memory tasks in patients with Parkinson's disease undergoing DBS surgery | Front Hum Neurosci | Buchanan RJ, Darrow DP, Meier KT, et al. | 2014 | 1662-5161 | |
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Publication TypeJournal ArticleAbstract
JournalFront Hum NeurosciPublication Volume8Publication Issue81Issn1662-5161AuthorsBuchanan RJ, Darrow DP, Meier KT, et al.DOI10.3389/fnhum.2014.00081 Google Scholar Pubmed |
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Toggle | Active vision in marmosets: a model system for visual neuroscience | J Neurosci | Mitchell JF, Reynolds JH, Miller CT | 2014 | 1529-2401 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ NeurosciPublication Volume34Publication Issue4Pagination1183-94Issn1529-2401AuthorsMitchell JF, Reynolds JH, Miller CTKeywordsAnimals, Callithrix, Conditioning, Operant, Models, Animal, Neurophysiology, Neurosciences, Saccades, Vision, Ocular, Visual PerceptionDOI10.1523/JNEUROSCI.3899-13.2014 Google Scholar Pubmed |
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Toggle | Using single-trial EEG to predict and analyze subsequent memory | Neuroimage | Noh E, Herzmann G, Curran T, et al. | 2014 | 1095-9572 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNeuroimagePublication Volume84Pagination712-23Issn1095-9572AuthorsNoh E, Herzmann G, Curran T, et al.KeywordsAdolescent, Adult, Brain, Electroencephalography, Humans, Male, Memory, Young AdultDOI10.1016/j.neuroimage.2013.09.028 Google Scholar Pubmed |
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Toggle | Independence of early speech processing from word meaning | Cereb Cortex | Travis KE, Leonard MK, Chan AM, et al. | 2013 | 1460-2199 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalCereb CortexPublication Volume23Publication Issue10Pagination2370-9Issn1460-2199AuthorsTravis KE, Leonard MK, Chan AM, et al.KeywordsAdult, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Magnetoencephalography, Male, Speech Perception, Young AdultDOI10.1093/cercor/bhs228 Google Scholar Pubmed |
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Toggle | Rats and humans differ in processing collinear visual features | Front Neural Circuits | Meier PM, Reinagel P | 2013 | 1662-5110 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalFront Neural CircuitsPublication Volume7Publication Issue197Issn1662-5110AuthorsMeier PM, Reinagel PKeywordsAnimals, Attention, Contrast Sensitivity, Humans, Orientation, Pattern Recognition, Visual, Photic Stimulation, Rats, Visual Cortex, Visual PerceptionDOI10.3389/fncir.2013.00197 Google Scholar Pubmed |
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Toggle | Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1 | J Neurosci | Nienborg H, Hasenstaub A, Nauhaus I, et al. | 2013 | 1529-2401 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ NeurosciPublication Volume33Publication Issue27Pagination11145-54Issn1529-2401AuthorsNienborg H, Hasenstaub A, Nauhaus I, et al.KeywordsAnimals, Contrast Sensitivity, Female, Male, Mice, Mice, Transgenic, Neurons, Parvalbumins, Photic Stimulation, Somatostatin, Space Perception, Visual CortexDOI10.1523/JNEUROSCI.5320-12.2013 Google Scholar Pubmed |
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Toggle | Neural stages of spoken, written, and signed word processing in beginning second language learners | Front Hum Neurosci | Leonard MK, Ramirez NFerjan, Torres C, et al. | 2013 | 1662-5161 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalFront Hum NeurosciPublication Volume7Publication Issue322Published2013/05/05Issn1662-5161AuthorsLeonard MK, Ramirez NFerjan, Torres C, et al.DOI10.3389/fnhum.2013.00322 Google Scholar Pubmed |
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Toggle | Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice | Elife | Deng W, Mayford M, Gage FH | 2013 | 2050-084X | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalElifePublication Volume2Paginatione00312Issn2050-084XAuthorsDeng W, Mayford M, Gage FHKeywordsAnimals, Behavior, Animal, Brain Mapping, CA1 Region, Hippocampal, Conditioning (Psychology), Cues, Dentate Gyrus, Environment, Fear, Gene Expression Regulation, Genes, Reporter, Memory, Memory, Episodic, Mental Recall, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Neural Pathways, Neurons, Pattern Recognition, Physiological, Time FactorsDOI10.7554/eLife.00312 Google Scholar Pubmed |
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Toggle | Evidence that primary visual cortex is required for image, orientation, and motion discrimination by rats | PLoS One | Petruno SK, Clark RE, Reinagel P | 2013 | 1932-6203 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalPLoS OnePublication Volume8Publication Issue2Paginatione56543Published2013/01/05Issn1932-6203AuthorsPetruno SK, Clark RE, Reinagel PKeywordsAnimals, Discrimination (Psychology), Discrimination Learning, Male, Motion, Orientation, Photic Stimulation, Psychomotor Performance, Rats, Visual CortexDOI10.1371/journal.pone.0056543 Google Scholar Pubmed |
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Toggle | Atypical social referencing in infant siblings of children with autism spectrum disorders | J Autism Dev Disord | Cornew L, Dobkins KR, Akshoomoff N, et al. | 2012 | 1573-3432 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ Autism Dev DisordPublication Volume42Publication Issue12Pagination2611-21Issn1573-3432AuthorsCornew L, Dobkins KR, Akshoomoff N, et al.KeywordsAttention, Child, Child Development, Child Development Disorders, Pervasive, Child, Preschool, Emotions, Endophenotypes, Female, Humans, Infant, Infant Behavior, Male, Risk Factors, Siblings, Social BehaviorDOI10.1007/s10803-012-1518-8 Google Scholar Pubmed |
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Toggle | Static sound timing alters sensitivity to low-level visual motion | J Vis | Kafaligonul H, Stoner GR | 2012 | 1534-7362 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ VisPublication Volume12Publication Issue11Issn1534-7362AuthorsKafaligonul H, Stoner GRKeywordsAcoustic Stimulation, Attention, Auditory Perception, Humans, Motion Perception, Photic Stimulation, Sound, Time PerceptionDOI10.1167/12.11.2 Google Scholar Pubmed |
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Toggle | Signed words in the congenitally deaf evoke typical late lexicosemantic responses with no early visual responses in left superior temporal cortex | J Neurosci | Leonard MK, Ramirez NFerjan, Torres C, et al. | 2012 | 1529-2401 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ NeurosciPublication Volume32Publication Issue28Pagination9700-5Issn1529-2401AuthorsLeonard MK, Ramirez NFerjan, Torres C, et al.KeywordsAdolescent, Adult, Brain Mapping, Deafness, Evoked Potentials, Female, Functional Laterality, Humans, Magnetic Fields, Magnetic Resonance Imaging, Magnetoencephalography, Male, Photic Stimulation, Semantics, Sign Language, Temporal Lobe, Time Factors, Young AdultDOI10.1523/JNEUROSCI.1002-12.2012 Google Scholar Pubmed |
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Toggle | Visual processing of contour patterns under conditions of inattentional blindness | J Cogn Neurosci | Pitts MA, Martínez A, Hillyard SA | 2012 | 1530-8898 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ Cogn NeurosciPublication Volume24Publication Issue2Pagination287-303Issn1530-8898AuthorsPitts MA, Martínez A, Hillyard SAKeywordsAdult, Attention, Awareness, Brain, Brain Mapping, Electroencephalography, Evoked Potentials, Visual, Female, Humans, Male, Perceptual Masking, Photic Stimulation, Reaction Time, Visual PerceptionDOI10.1162/jocn_a_00111 Google Scholar Pubmed |
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Toggle | The marmoset monkey as a model for visual neuroscience | Neurosci Res | Mitchell JF, Leopold DA | 2015 | 1872-8111 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNeurosci ResPublication Volume93Pagination20-46Issn1872-8111AuthorsMitchell JF, Leopold DAKeywordsAnimals, Biological Evolution, Brain, Callithrix, Color Perception, Color Vision, Exploratory Behavior, Macaca, Models, Animal, Social Behavior, Vision, Binocular, Vision, Ocular, Visual PerceptionDOI10.1016/j.neures.2015.01.008 Google Scholar Pubmed |
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Toggle | Neural substrates of time perception and impulsivity | Brain Res | Wittmann M, Simmons AN, Flagan T, et al. | 2011 | 1872-6240 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalBrain ResPublication Volume1406Pagination43-58Issn1872-6240AuthorsWittmann M, Simmons AN, Flagan T, et al.KeywordsAdolescent, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Personality Inventory, Reaction Time, Self Report, Surveys and Questionnaires, Time Factors, Time Perception, Young AdultDOI10.1016/j.brainres.2011.06.048 Google Scholar Pubmed |
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Toggle | Spatiotemporal neural dynamics of word understanding in 12- to 18-month-old-infants | Cereb Cortex | Travis KE, Leonard MK, Brown TT, et al. | 2011 | 1460-2199 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalCereb CortexPublication Volume21Publication Issue8Pagination1832-9Issn1460-2199AuthorsTravis KE, Leonard MK, Brown TT, et al.KeywordsAdult, Brain Mapping, Cerebral Cortex, Evoked Potentials, Auditory, Female, Humans, Infant, Language Tests, Learning, Magnetic Resonance Imaging, Magnetoencephalography, Male, Neurons, Speech Perception, VocabularyDOI10.1093/cercor/bhq259 Google Scholar Pubmed |
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Toggle | Collinear features impair visual detection by rats | J Vis | Meier P, Flister E, Reinagel P | 2011 | 1534-7362 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ VisPublication Volume11Publication Issue3Issn1534-7362AuthorsMeier P, Flister E, Reinagel PKeywordsAnimals, Behavior, Animal, Conditioning (Psychology), Contrast Sensitivity, Lighting, Orientation, Photic Stimulation, Psychophysics, Rats, Retina, Space PerceptionDOI10.1167/11.3.22 Google Scholar Pubmed |
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Toggle | Rat performance on visual detection task modeled with divisive normalization and adaptive decision thresholds | J Vis | Meier P, Reinagel P | 2011 | 1534-7362 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ VisPublication Volume11Publication Issue9Published2011/01/14Issn1534-7362AuthorsMeier P, Reinagel PKeywordsAdaptation, Physiological, Animals, Choice Behavior, Cognition, Conditioning (Psychology), Contrast Sensitivity, Male, Models, Neurological, Photic Stimulation, Psychomotor Performance, Rats, Rats, Long-Evans, Visual PerceptionDOI10.1167/11.9.1 Google Scholar Pubmed |
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Toggle | Language proficiency modulates the recruitment of non-classical language areas in bilinguals | PLoS One | Leonard MK, Torres C, Travis KE, et al. | 2011 | 1932-6203 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalPLoS OnePublication Volume6Publication Issue3Paginatione18240Issn1932-6203AuthorsLeonard MK, Torres C, Travis KE, et al.KeywordsAdult, Brain Mapping, Female, Humans, Language, Language Development, Magnetic Resonance Imaging, Magnetoencephalography, Male, Multilingualism, Young AdultDOI10.1371/journal.pone.0018240 Google Scholar Pubmed |
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Toggle | Hippocampal signals for strong memory when associative memory is available and when it is not | Hippocampus | Wais PE | 2011 | 1098-1063 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalHippocampusPublication Volume21Publication Issue1Pagination9-21Issn1098-1063AuthorsWais PEKeywordsBrain Mapping, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, MemoryDOI10.1002/hipo.20716 Google Scholar Pubmed |
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Toggle | Sustained dorsal hippocampal activity is not obligatory for either the maintenance or retrieval of long-term spatial memory | Hippocampus | Broadbent NJ, Squire LR, Clark RE | 2010 | 1098-1063 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalHippocampusPublication Volume20Publication Issue12Pagination1366-75Issn1098-1063AuthorsBroadbent NJ, Squire LR, Clark REDOI10.1002/hipo.20722 Google Scholar Pubmed |
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Toggle | Targeting single neuronal networks for gene expression and cell labeling in vivo | Neuron | Marshel JH, Mori T, Nielsen KJ, et al. | 2010 | 1097-4199 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNeuronPublication Volume67Publication Issue4Pagination562-74Issn1097-4199AuthorsMarshel JH, Mori T, Nielsen KJ, et al.DOI10.1016/j.neuron.2010.08.001 Google Scholar Pubmed |
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Toggle | Accumulation of neural activity in the posterior insula encodes the passage of time | Neuropsychologia | Wittmann M, Simmons AN, Aron JL, et al. | 2010 | 1873-3514 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNeuropsychologiaPublication Volume48Publication Issue10Pagination3110-20Published2010/08/02Issn1873-3514AuthorsWittmann M, Simmons AN, Aron JL, et al.KeywordsAdult, Analysis of Variance, Brain Mapping, Cerebral Cortex, Factor Analysis, Statistical, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Reaction Time, Time Factors, Time Perception, Young AdultDOI10.1016/j.neuropsychologia.2010.06.023 Google Scholar Pubmed |
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Toggle | Adult neurogenesis: integrating theories and separating functions | Trends Cogn Sci | Aimone JB, Deng W, Gage FH | 2010 | 1879-307X | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalTrends Cogn SciPublication Volume14Publication Issue7Pagination325-37Published2010/07/07Issn1879-307XAuthorsAimone JB, Deng W, Gage FHKeywordsAdult, Adult Stem Cells, Animals, Cell Proliferation, Hippocampus, Humans, Models, Biological, Neurogenesis, NeuronsDOI10.1016/j.tics.2010.04.003 Google Scholar Pubmed |
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Toggle | New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? | Nat Rev Neurosci | Deng W, Aimone JB, Gage FH | 2010 | 1471-0048 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNat Rev NeurosciPublication Volume11Publication Issue5Pagination339-50Published2010/05/05Issn1471-0048AuthorsDeng W, Aimone JB, Gage FHKeywordsAdult Stem Cells, Animals, Hippocampus, Humans, Learning, Memory, Models, Neurological, Neurogenesis, NeuronsDOI10.1038/nrn2822 Google Scholar Pubmed |
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Toggle | Now or later? Striatum and insula activation to immediate versus delayed rewards | J Neurosci Psychol Econ | Wittmann M, Lovero KL, Lane SD, et al. | 2010 | 1937-321X | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ Neurosci Psychol EconPublication Volume3Publication Issue1Pagination15-26Issn1937-321XAuthorsWittmann M, Lovero KL, Lane SD, et al.DOI10.1037/a0017252 Google Scholar Pubmed |
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Toggle | Spatiotemporal dynamics of bilingual word processing | Neuroimage | Leonard MK, Brown TT, Travis KE, et al. | 2010 | 1095-9572 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalNeuroimagePublication Volume49Publication Issue4Pagination3286-94Published2010/02/15Issn1095-9572AuthorsLeonard MK, Brown TT, Travis KE, et al.DOI10.1016/j.neuroimage.2009.12.009 Google Scholar Pubmed |
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Toggle | Auditory modulation of visual apparent motion with short spatial and temporal intervals | J Vis | Kafaligonul H, Stoner GR | 2010 | 1534-7362 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ VisPublication Volume10Publication Issue12Pagination31Issn1534-7362AuthorsKafaligonul H, Stoner GRKeywordsAcoustic Stimulation, Auditory Perception, Humans, Motion Perception, Photic Stimulation, Temporal Lobe, Time Perception, Visual CortexDOI10.1167/10.12.31 Google Scholar Pubmed |
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Toggle | Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism | Biol Psychiatry | McCleery JP, Akshoomoff N, Dobkins KR, et al. | 2009 | 1873-2402 | |
PubMed Record
Publication TypeJournal ArticleAbstractBACKGROUND: Previous studies have documented atypicalities in face/object processing in children and adults with autism spectrum disorders (ASDs). To investigate whether such atypicalities may reflect a genetically mediated risk factor present early in development, we measured face/object processing in 10-month-old high-risk infants who carry some of the genes associated with ASD because they have an older sibling diagnosed with the disorder. METHODS: We employed event-related potentials (ERPs) to measure cortical responses to pictures of faces and objects, the objects being toys. Latencies and amplitudes of four ERP components (P100, N290, P400, and Nc) were compared between 20 high-risk infants and 20 low-risk control subjects (infants with no family history of ASD). RESULTS: Responses to faces versus objects differed between high- and low-risk infants for the latencies of the N290 and P400. Differences were driven by faster responses to faces than objects in low-risk, but not high-risk, infants (P400) and, conversely, faster responses to objects than faces in high-risk, but not low-risk, infants (N290). Object responses were also faster in high-risk than low-risk infants (both N290 and P400). Left versus right hemisphere responses also differed between high- and low-risk infants for the amplitudes of the P100, N290, and P400; collapsed across faces/objects, low-risk, but not high-risk, infants exhibited hemisphere asymmetries. CONCLUSIONS: Genetic risk for ASD is associated with atypical face versus object processing and an atypical lack of hemispheric asymmetry early in life. These atypicalities might contribute to development of the disorder. JournalBiol PsychiatryPublication Volume66Publication Issue10Pagination950-7Issn1873-2402AuthorsMcCleery JP, Akshoomoff N, Dobkins KR, et al.DOI10.1016/j.biopsych.2009.07.031 Google Scholar Pubmed |
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Toggle | Effects of gestational length, gender, postnatal age, and birth order on visual contrast sensitivity in infants | J Vis | Dobkins KR, Bosworth RG, McCleery JP | 2009 | 1534-7362 | |
PubMed Record
Publication TypeJournal ArticleAbstract
JournalJ VisPublication Volume9Publication Issue10Pagination19.1-21Issn1534-7362AuthorsDobkins KR, Bosworth RG, McCleery JPDOI10.1167/9.10.19 Google Scholar Pubmed |
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Toggle | Temporal horizons in decision making | Journal of Neuroscience, Psychology, and Economics | Wittmann M, Paulus MP | 2009 | 1946-1941 | |
Publication TypeJournal ArticleAbstractThe perception of duration is crucial when we make choices between immediate and delayed rewards. Immediate rewards are valued more than the same rewards if they are delayed. Preferences for earlier rewards become even stronger when the reward can be received within a subjectively proximate time frame. A “rational” decision to wait for a delayed reward may be overruled by an “impulsive” choice when the option for the closer reward falls within this proximate time range. Based on findings on circadian and circannual physiological rhythms, we suggest that there are 2 time units that are both biologically and culturally determined and have an impact on human experience and behavior: the day and the year. We highlight results of a neuroimaging study showing that rewards with delays up to 1 year are discounted differently than reward delays longer than 1 year. This duration-dependent discounting is associated with specific brain activation in the striatum. We present various conceptualizations of subjective time incorporated in parametric models of intertemporal decisions that may lead to a better understanding of human choice behavior. (PsycINFO Database Record (c) 2016 APA, all rights reserved) JournalJournal of Neuroscience, Psychology, and EconomicsPublication Volume2Publication Issue1Pagination1-11Issn1946-1941AuthorsWittmann M, Paulus MPDOIGoogle Scholar Pubmed |
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Toggle | Computational influence of adult neurogenesis on memory encoding | Neuron | Aimone JB, Wiles J, Gage FH | 2009 | 1097-4199 | |
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Publication TypeJournal ArticleAbstract
JournalNeuronPublication Volume61Publication Issue2Pagination187-202Issn1097-4199AuthorsAimone JB, Wiles J, Gage FHDOI10.1016/j.neuron.2008.11.026 Google Scholar Pubmed |