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Toggle Computational influence of adult neurogenesis on memory encoding Neuron Aimone JB, Wiles J, Gage FH 2009 1097-4199
PubMed Record

Publication Type

Journal Article

Abstract

Adult neurogenesis in the hippocampus leads to the incorporation of thousands of new granule cells into the dentate gyrus every month, but its function remains unclear. Here, we present computational evidence that indicates that adult neurogenesis may make three separate but related contributions to memory formation. First, immature neurons introduce a degree of similarity to memories learned at the same time, a process we refer to as pattern integration. Second, the extended maturation and change in excitability of these neurons make this added similarity a time-dependent effect, supporting the possibility that temporal information is included in new hippocampal memories. Finally, our model suggests that the experience-dependent addition of neurons results in a dentate gyrus network well suited for encoding new memories in familiar contexts while treating novel contexts differently. Taken together, these results indicate that new granule cells may affect hippocampal function in several unique and previously unpredicted ways.

Journal

Neuron

Publication Volume

61

Publication Issue

2

Pagination

187-202

Issn

1097-4199

Authors

Aimone JB, Wiles J, Gage FH

DOI

10.1016/j.neuron.2008.11.026 Google Scholar  Pubmed