Marmosets: A Neuroscientific Model of Human Social Behavior.

TitleMarmosets: A Neuroscientific Model of Human Social Behavior.
Publication TypeJournal Article
Year of Publication2016
AuthorsMiller CT, Freiwald WA, Leopold DA, Mitchell JF, Silva AC, Wang X
Date Published2016 04 20
KeywordsAnimals, Animals, Genetically Modified, Brain, Callithrix, Cognition, Disease Models, Animal, Eye Movements, Haplorhini, Humans, Models, Animal, Rodentia, Social Behavior, Social Behavior Disorders, Vocalization, Animal

The common marmoset (Callithrix jacchus) has garnered interest recently as a powerful model for the future of neuroscience research. Much of this excitement has centered on the species' reproductive biology and compatibility with gene editing techniques, which together have provided a path for transgenic marmosets to contribute to the study of disease as well as basic brain mechanisms. In step with technical advances is the need to establish experimental paradigms that optimally tap into the marmosets' behavioral and cognitive capacities. While conditioned task performance of a marmoset can compare unfavorably with rhesus monkey performance on conventional testing paradigms, marmosets' social behavior and cognition are more similar to that of humans. For example, marmosets are among only a handful of primates that, like humans, routinely pair bond and care cooperatively for their young. They are also notably pro-social and exhibit social cognitive abilities, such as imitation, that are rare outside of the Apes. In this Primer, we describe key facets of marmoset natural social behavior and demonstrate that emerging behavioral paradigms are well suited to isolate components of marmoset cognition that are highly relevant to humans. These approaches generally embrace natural behavior, which has been rare in conventional primate testing, and thus allow for a new consideration of neural mechanisms underlying primate social cognition and signaling. We anticipate that through parallel technical and paradigmatic advances, marmosets will become an essential model of human social behavior, including its dysfunction in neuropsychiatric disorders.

Alternate JournalNeuron
PubMed ID27100195
PubMed Central IDPMC4840471
Grant ListR21 MH104756 / MH / NIMH NIH HHS / United States
ZIA MH002898 / MH / NIMH NIH HHS / United States
ZIA MH002838 / MH / NIMH NIH HHS / United States
U01 NS094330 / NS / NINDS NIH HHS / United States
R01 DC012087 / DC / NIDCD NIH HHS / United States
R01 DC003180 / DC / NIDCD NIH HHS / United States
R01 DC005808 / DC / NIDCD NIH HHS / United States
IRG Funded