|Title||Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Ward S, Riley C, Carey EM, Nguyen J, Esener S, Nimmerjahn A, Sirbuly DJ|
|Date Published||2022 Jun 07|
Central to advancing our understanding of neural circuits is developing minimally invasive, multi-modal interfaces capable of simultaneously recording and modulating neural activity. Recent devices have focused on matching the mechanical compliance of tissue to reduce inflammatory responses. However, reductions in the size of multi-modal interfaces are needed to further improve biocompatibility and long-term recording capabilities. Here a multi-modal coaxial microprobe design with a minimally invasive footprint (8-14 µm diameter over millimeter lengths) that enables efficient electrical and optical interrogation of neural networks is presented. In the brain, the probes allowed robust electrical measurement and optogenetic stimulation. Scalable fabrication strategies can be used with various electrical and optical materials, making the probes highly customizable to experimental requirements, including length, diameter, and mechanical properties. Given their negligible inflammatory response, these probes promise to enable a new generation of readily tunable multi-modal devices for long-term, minimally invasive interfacing with neural circuits.
|Alternate Journal||Nat Commun|
|Grant List||HR0011-16-2-0027 / / United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) / |
R01 NS108034 / NS / NINDS NIH HHS / United States
U19 NS112959 / NS / NINDS NIH HHS / United States
U01 NS103522 / NS / NINDS NIH HHS / United States
P30CA014195 / / U.S. Department of Health & Human Services | National Institutes of Health (NIH) /
ECCS-1542148 / / National Science Foundation (NSF) /
Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits.