Title | The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Kent CF, Daskalchuk T, Cook L, Sokolowski MB, Greenspan RJ |
Journal | PLoS Genet |
Volume | 5 |
Issue | 8 |
Pagination | e1000609 |
Date Published | 2009 Aug |
ISSN | 1553-7404 |
Keywords | Animals, Carbohydrate Metabolism, Cyclic GMP-Dependent Protein Kinases, Drosophila melanogaster, Drosophila Proteins, Ecosystem, Fats, Food Deprivation, Gene Expression, Signal Transduction |
Abstract | Nutrition is known to interact with genotype in human metabolic syndromes, obesity, and diabetes, and also in Drosophila metabolism. Plasticity in metabolic responses, such as changes in body fat or blood sugar in response to changes in dietary alterations, may also be affected by genotype. Here we show that variants of the foraging (for) gene in Drosophila melanogaster affect the response to food deprivation in a large suite of adult phenotypes by measuring gene by environment interactions (GEI) in a suite of food-related traits. for affects body fat, carbohydrates, food-leaving behavior, metabolite, and gene expression levels in response to food deprivation. This results in broad patterns of metabolic, genomic, and behavioral gene by environment interactions (GEI), in part by interaction with the insulin signaling pathway. Our results show that a single gene that varies in nature can have far reaching effects on behavior and metabolism by acting through multiple other genes and pathways. |
DOI | 10.1371/journal.pgen.1000609 |
Alternate Journal | PLoS Genet. |
PubMed ID | 19696884 |
PubMed Central ID | PMC2720453 |
Grant List | DK70141-2 / DK / NIDDK NIH HHS / United States |
The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation.
Category:
Top Cited Publication of the ORU
Greenspan Laboratory