@article {174,
	title = {Adult neurogenesis: integrating theories and separating functions.},
	journal = {Trends Cogn Sci},
	volume = {14},
	year = {2010},
	month = {2010 Jul},
	pages = {325-37},
	abstract = {<p>The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.</p>
},
	keywords = {Adult, Adult Stem Cells, Animals, Cell Proliferation, Hippocampus, Humans, Models, Biological, Neurogenesis, Neurons},
	issn = {1879-307X},
	doi = {10.1016/j.tics.2010.04.003},
	author = {Aimone, James B and Deng, Wei and Gage, Fred H}
}
@article {175,
	title = {Computational influence of adult neurogenesis on memory encoding.},
	journal = {Neuron},
	volume = {61},
	year = {2009},
	month = {2009 Jan 29},
	pages = {187-202},
	abstract = {<p>Adult neurogenesis in the hippocampus leads to the incorporation of thousands of new granule cells into the dentate gyrus every month, but its function remains unclear. Here, we present computational evidence that indicates that adult neurogenesis may make three separate but related contributions to memory formation. First, immature neurons introduce a degree of similarity to memories learned at the same time, a process we refer to as pattern integration. Second, the extended maturation and change in excitability of these neurons make this added similarity a time-dependent effect, supporting the possibility that temporal information is included in new hippocampal memories. Finally, our model suggests that the experience-dependent addition of neurons results in a dentate gyrus network well suited for encoding new memories in familiar contexts while treating novel contexts differently. Taken together, these results indicate that new granule cells may affect hippocampal function in several unique and previously unpredicted ways.</p>
},
	keywords = {Age Factors, Algorithms, Animals, Cell Proliferation, Computer Simulation, Dentate Gyrus, Humans, Memory, Nerve Net, Neural Pathways, Neurogenesis, Neuronal Plasticity, Neurons, Stem Cells, Synapses, Time Perception},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2008.11.026},
	author = {Aimone, James B and Wiles, Janet and Gage, Fred H}
}
