@article {2188,
	title = {Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases.},
	journal = {Science},
	volume = {375},
	year = {2022},
	month = {2022 02 04},
	pages = {522-528},
	abstract = {<p>To determine the impact of genetic variants on the brain, we used genetically informed brain atlases in genome-wide association studies of regional cortical surface area and thickness in 39,898 adults and 9136 children. We uncovered 440 genome-wide significant loci in the discovery cohort and 800 from a post hoc combined meta-analysis. Loci in adulthood were largely captured in childhood, showing signatures of negative selection, and were linked to early neurodevelopment and pathways associated with neuropsychiatric risk. Opposing gradations of decreased surface area and increased thickness were associated with common inversion polymorphisms. Inferior frontal regions, encompassing Broca{\textquoteright}s area, which is important for speech, were enriched for human-specific genomic elements. Thus, a mixed genetic landscape of conserved and human-specific features is concordant with brain hierarchy and morphogenetic gradients.</p>
},
	keywords = {Adult, Aged, Aged, 80 and over, Cerebral Cortex, Child, Chromatin, Cohort Studies, Female, Gene Ontology, Genetic Association Studies, Genetic Loci, Genetic Variation, Genome, Human, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Molecular Sequence Annotation, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Regulatory Sequences, Nucleic Acid},
	issn = {1095-9203},
	doi = {10.1126/science.abe8457},
	author = {Makowski, Carolina and van der Meer, Dennis and Dong, Weixiu and Wang, Hao and Wu, Yan and Zou, Jingjing and Liu, Cin and Rosenthal, Sara B and Hagler, Donald J and Fan, Chun Chieh and Kremen, William S and Andreassen, Ole A and Jernigan, Terry L and Dale, Anders M and Zhang, Kun and Visscher, Peter M and Yang, Jian and Chen, Chi-Hua}
}
@article {146,
	title = {The nature of genetic influences on behavior: lessons from "simpler" organisms.},
	journal = {Am J Psychiatry},
	volume = {163},
	year = {2006},
	month = {2006 Oct},
	pages = {1683-94},
	abstract = {<p>Substantial advances have been made in recent years in the understanding of the genetic basis of behavior in "simpler" organisms, especially the mouse and the fruit fly Drosophila. The authors examine the degree of similarity between the genetic underpinnings of psychiatric illness and genetic influences on behavior in such simpler organisms. Six topics are reviewed: 1) the extent of natural genetic variation, 2) the multigenic nature of natural variation, 3) the impact of individual genes on multiple traits, 4) gene-environment interactions, 5) genetic effects on the environment, and 6) gene-by-sex interactions. The results suggest that the pattern of results emerging in psychiatric genetics is generally consistent with the findings of behavioral genetics in simpler organisms. Across the animal kingdom, individual differences in behavior are nearly always influenced by genetic factors which, in turn, result from a substantial number of individual genes, each with a small effect. Nearly all genes that affect behavior influence multiple phenotypes. The impact of individual genes can be substantially modified by other genes and/or by environmental experiences. Many animals alter their environment, and the nature of that alteration is influenced by genes. For some behaviors, the pathway from genes to behavior differs meaningfully in males and females. With respect to the broad patterns of genetic influences on behavior, Homo sapiens appears to be typical of other animal species.</p>
},
	keywords = {Animals, Drosophila, Genetics, Behavioral, Humans, Mental Disorders, Mice, Physiology, Comparative},
	issn = {0002-953X},
	doi = {10.1176/ajp.2006.163.10.1683},
	author = {Kendler, Kenneth S and Greenspan, Ralph J}
}
