| Title | Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Osborne KA, Robichon A, Burgess E, Butland S, Shaw RA, Coulthard A, Pereira HS, Greenspan RJ, Sokolowski MB |
| Journal | Science |
| Volume | 277 |
| Issue | 5327 |
| Pagination | 834-6 |
| Date Published | 1997 Aug 8 |
| ISSN | 0036-8075 |
| Keywords | Animals, Animals, Genetically Modified, Cyclic GMP, Cyclic GMP-Dependent Protein Kinases, Drosophila melanogaster, Feeding Behavior, Genes, Insect, Larva, Phenotype, Polymorphism, Genetic, Signal Transduction |
| Abstract | Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 complementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism. |
| Alternate Journal | Science |
| PubMed ID | 9242616 |
Category:
Greenspan Laboratory
