Title | Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Brennand KJ, M Marchetto C, Benvenisty N, Brüstle O, Ebert A, Belmonte JCarlos Izp, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R |
Journal | Stem Cell Reports |
Volume | 5 |
Issue | 6 |
Pagination | 933-45 |
Date Published | 2015 Dec 8 |
ISSN | 2213-6711 |
Abstract | As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field. |
DOI | 10.1016/j.stemcr.2015.10.011 |
Alternate Journal | Stem Cell Reports |
PubMed ID | 26610635 |
PubMed Central ID | PMC4881284 |
Grant List | 101052 / / Wellcome Trust / United Kingdom 2R01MH104610 / MH / NIMH NIH HHS / United States MC_UP_1201/9 / / Medical Research Council / United Kingdom P01NS066888 / NS / NINDS NIH HHS / United States P50MH094268 / MH / NIMH NIH HHS / United States R01 MH102418 / MH / NIMH NIH HHS / United States R01 MH105442 / MH / NIMH NIH HHS / United States R01MH089176 / MH / NIMH NIH HHS / United States R01MH092443 / MH / NIMH NIH HHS / United States R01MH094753 / MH / NIMH NIH HHS / United States R01MH095741 / MH / NIMH NIH HHS / United States R01MH101454 / MH / NIMH NIH HHS / United States R01MH102418 / MH / NIMH NIH HHS / United States R01MH103134 / MH / NIMH NIH HHS / United States R01MH105442 / MH / NIMH NIH HHS / United States R01MH105660 / MH / NIMH NIH HHS / United States R01NS047344 / NS / NINDS NIH HHS / United States R01NS088538 / NS / NINDS NIH HHS / United States R21MH087879 / MH / NIMH NIH HHS / United States R33MH087874 / MH / NIMH NIH HHS / United States RF1AG042932 / AG / NIA NIH HHS / United States U01 MH103365 / MH / NIMH NIH HHS / United States U01MH1068821 / MH / NIMH NIH HHS / United States U19MH107367 / MH / NIMH NIH HHS / United States / / Wellcome Trust / United Kingdom |
Category:
Gage Laboratory