Adult neurogenesis: integrating theories and separating functions.

TitleAdult neurogenesis: integrating theories and separating functions.
Publication TypeJournal Article
Year of Publication2010
AuthorsAimone JB, Deng W, Gage FH
JournalTrends Cogn Sci
Date Published2010 Jul
KeywordsAdult, Adult Stem Cells, Animals, Cell Proliferation, Hippocampus, Humans, Models, Biological, Neurogenesis, Neurons

The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.

Alternate JournalTrends Cogn. Sci. (Regul. Ed.)
PubMed ID20471301
PubMed Central IDPMC2904863
Grant ListMH-090258 / MH / NIMH NIH HHS / United States
R01 MH090258 / MH / NIMH NIH HHS / United States
R01 MH090258-01 / MH / NIMH NIH HHS / United States
IRG Funded
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