|Title||Adult neurogenesis: integrating theories and separating functions.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Aimone JB, Deng W, Gage FH|
|Journal||Trends Cogn Sci|
|Date Published||2010 Jul|
|Keywords||Adult, Adult Stem Cells, Animals, Cell Proliferation, Hippocampus, Humans, Models, Biological, Neurogenesis, Neurons|
The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.
|Alternate Journal||Trends Cogn. Sci. (Regul. Ed.)|
|PubMed Central ID||PMC2904863|
|Grant List||MH-090258 / MH / NIMH NIH HHS / United States |
R01 MH090258 / MH / NIMH NIH HHS / United States
R01 MH090258-01 / MH / NIMH NIH HHS / United States
Adult neurogenesis: integrating theories and separating functions.
Top Cited Publication of the ORU