| Title | Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Foltenyi K, Greenspan RJ, Newport JW |
| Journal | Nat Neurosci |
| Volume | 10 |
| Issue | 9 |
| Pagination | 1160-7 |
| Date Published | 2007 Sep |
| ISSN | 1097-6256 |
| Keywords | Analysis of Variance, Animals, Animals, Genetically Modified, Behavior, Animal, Drosophila, Drosophila Proteins, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Developmental, Membrane Proteins, Motor Activity, Receptor, Epidermal Growth Factor, Signal Transduction, Sleep |
| Abstract | Epidermal growth factor receptor (EGFR) signaling in the mammalian hypothalamus is important in the circadian regulation of activity. We have examined the role of this pathway in the regulation of sleep in Drosophila melanogaster. Our results demonstrate that rhomboid (Rho)- and Star-mediated activation of EGFR and ERK signaling increases sleep in a dose-dependent manner, and that blockade of rhomboid (rho) expression in the nervous system decreases sleep. The requirement of rho for sleep localized to the pars intercerebralis, a part of the fly brain that is developmentally and functionally analogous to the hypothalamus in vertebrates. These results suggest that sleep and its regulation by EGFR signaling may be ancestral to insects and mammals. |
| DOI | 10.1038/nn1957 |
| Alternate Journal | Nat. Neurosci. |
| PubMed ID | 17694052 |
Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila.
Category:
Greenspan Laboratory
