@article {2288,
	title = {Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits.},
	journal = {Nat Commun},
	volume = {13},
	year = {2022},
	month = {2022 Jun 07},
	pages = {3286},
	abstract = {<p>Central to advancing our understanding of neural circuits is developing minimally invasive, multi-modal interfaces capable of simultaneously recording and modulating neural activity. Recent devices have focused on matching the mechanical compliance of tissue to reduce inflammatory responses. However, reductions in the size of multi-modal interfaces are needed to further improve biocompatibility and long-term recording capabilities. Here a multi-modal coaxial microprobe design with a minimally invasive footprint (8-14 {\textmu}m diameter over millimeter lengths) that enables efficient electrical and optical interrogation of neural networks is presented. In the brain, the probes allowed robust electrical measurement and optogenetic stimulation. Scalable fabrication strategies can be used with various electrical and optical materials, making the probes highly customizable to experimental requirements, including length, diameter, and mechanical properties. Given their negligible inflammatory response, these probes promise to enable a new generation of readily tunable multi-modal devices for long-term, minimally invasive interfacing with neural circuits.</p>
},
	keywords = {Brain, Optogenetics},
	issn = {2041-1723},
	doi = {10.1038/s41467-022-30275-x},
	author = {Ward, Spencer and Riley, Conor and Carey, Erin M and Nguyen, Jenny and Esener, Sadik and Nimmerjahn, Axel and Sirbuly, Donald J}
}
@article {1680,
	title = {Optogenetic manipulation of neural circuits in awake marmosets.},
	journal = {J Neurophysiol},
	volume = {116},
	year = {2016},
	month = {2016 09 01},
	pages = {1286-94},
	abstract = {<p>Optogenetics has revolutionized the study of functional neuronal circuitry (Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Nat Neurosci 8: 1263-1268, 2005; Deisseroth K. Nat Methods 8: 26-29, 2011). Although these techniques have been most successfully implemented in rodent models, they have the potential to be similarly impactful in studies of nonhuman primate brains. Common marmosets (Callithrix jacchus) have recently emerged as a candidate primate model for gene editing, providing a potentially powerful model for studies of neural circuitry and disease in primates. The application of viral transduction methods in marmosets for identifying and manipulating neuronal circuitry is a crucial step in developing this species for neuroscience research. In the present study we developed a novel, chronic method to successfully induce rapid photostimulation in individual cortical neurons transduced by adeno-associated virus to express channelrhodopsin (ChR2) in awake marmosets. We found that large proportions of neurons could be effectively photoactivated following viral transduction and that this procedure could be repeated for several months. These data suggest that techniques for viral transduction and optical manipulation of neuronal populations are suitable for marmosets and can be combined with existing behavioral preparations in the species to elucidate the functional neural circuitry underlying perceptual and cognitive processes.</p>
},
	keywords = {Action Potentials, Animals, Bacterial Proteins, Brain, Callithrix, Dependovirus, Female, Genetic Vectors, Luminescent Proteins, Microelectrodes, Models, Animal, Neural Pathways, Neurons, Optogenetics, Photic Stimulation, Rhodopsin, Serogroup, Wakefulness},
	issn = {1522-1598},
	doi = {10.1152/jn.00197.2016},
	author = {MacDougall, Matthew and Nummela, Samuel U and Coop, Shanna and Disney, Anita and Mitchell, Jude F and Miller, Cory T}
}
