@article {1468,
	title = {Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference.},
	journal = {Neuron},
	volume = {95},
	year = {2017},
	month = {2017 Sep 13},
	pages = {1319-1333.e5},
	abstract = {<p>Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons during development. We show that protracted exposure to kin or non-kin odorants\&nbsp;changes the number of dopamine (DA)- or gamma aminobutyric acid (GABA)-expressing neurons, with\&nbsp;corresponding changes in attraction/aversion behavior. Changing the relative number of dopaminergic and GABAergic AOB interneurons or locally introducing DA or GABA receptor antagonists alters kinship preference. We then isolate AOB microRNAs (miRs) differentially regulated across these conditions. Inhibition of miR-375 and miR-200b reveals that they target Pax6 and Bcl11b to regulate the dopaminergic and GABAergic phenotypes. The results illuminate the role of NT switching governing experience-dependent social preference. VIDEO ABSTRACT.</p>
},
	keywords = {Animals, Choice Behavior, Dopamine, Dopamine Antagonists, GABA Antagonists, gamma-Aminobutyric Acid, Interneurons, MicroRNAs, Neurons, Neurotransmitter Agents, Olfactory Bulb, PAX6 Transcription Factor, Pheromones, Siblings, Social Behavior, Transcription Factors, Xenopus laevis, Xenopus Proteins},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2017.08.023},
	author = {Dulcis, Davide and Lippi, Giordano and Stark, Christiana J and Do, Long H and Berg, Darwin K and Spitzer, Nicholas C}
}
@article {181,
	title = {Atypical social referencing in infant siblings of children with autism spectrum disorders.},
	journal = {J Autism Dev Disord},
	volume = {42},
	year = {2012},
	month = {2012 Dec},
	pages = {2611-21},
	abstract = {<p>Social referencing was investigated in 18-month-old siblings of children with autism spectrum disorders (ASD; "high-risk infants"). Infants were exposed to novel toys, which were emotionally tagged via adults{\textquoteright} facial and vocal signals. Infants{\textquoteright} information seeking (initiation of joint attention with an adult) and their approach/withdrawal behavior toward the toys before versus after the adults{\textquoteright} emotional signals was measured. Compared to both typically developing infants and high-risk infants without ASD, infants later diagnosed with ASD engaged in slower information seeking, suggesting that this aspect of referencing may be an early indicator of ASD. High-risk infants, both those who were and those who were not later diagnosed with ASD, exhibited impairments in regulating their behavior based on the adults{\textquoteright} emotional signals, suggesting that this aspect of social referencing may reflect an endophenotype for ASD.</p>
},
	keywords = {Attention, Child, Child Development, Child Development Disorders, Pervasive, Child, Preschool, Emotions, Endophenotypes, Female, Humans, Infant, Infant Behavior, Male, Risk Factors, Siblings, Social Behavior},
	issn = {1573-3432},
	doi = {10.1007/s10803-012-1518-8},
	author = {Cornew, Lauren and Dobkins, Karen R and Akshoomoff, Natacha and McCleery, Joseph P and Carver, Leslie J}
}
