Title | New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Deng W, Aimone JB, Gage FH |
Journal | Nat Rev Neurosci |
Volume | 11 |
Issue | 5 |
Pagination | 339-50 |
Date Published | 2010 May |
ISSN | 1471-0048 |
Keywords | Adult Stem Cells, Animals, Hippocampus, Humans, Learning, Memory, Models, Neurological, Neurogenesis, Neurons |
Abstract | The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function in these processes has remained elusive. In this article, we summarize recent progress in this area, including advances based on behavioural studies and insights provided by computational modelling. Increasingly, evidence suggests that newborn neurons might be involved in hippocampal functions that are particularly dependent on the dentate gyrus, such as pattern separation. Furthermore, newborn neurons at different maturation stages may make distinct contributions to learning and memory. In particular, computational studies suggest that, before newborn neurons are fully mature, they might function as a pattern integrator by introducing a degree of similarity to the encoding of events that occur closely in time. |
DOI | 10.1038/nrn2822 |
Alternate Journal | Nat. Rev. Neurosci. |
PubMed ID | 20354534 |
PubMed Central ID | PMC2886712 |
Grant List | AG-020938 / AG / NIA NIH HHS / United States NS-050217 / NS / NINDS NIH HHS / United States R01 AG020938 / AG / NIA NIH HHS / United States R01 AG020938-05 / AG / NIA NIH HHS / United States R01 NS050217 / NS / NINDS NIH HHS / United States R01 NS050217-05 / NS / NINDS NIH HHS / United States |
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Category:
IRG Funded
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